ITAC (CXCL11) Recombinant Protein | ITAC recombinant protein
Human ITAC (CXCL11) Recombinant
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
and propeptide and has a calculated molecular mass of approximately 8 kDa.
Recombinant CXCL11 is a disulfide-linked monomeric protein consisting of 74 amino acid residue subunits and migrates as an approximately 8 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
• th1 cells express ifn-gamma, and m1 macrophages ccl19/CXCL11 and il-17/il-18/il-23 in sympathetic ophthalmia .Invest. Ophthalmol. Vis. Sci., Apr 2009; 50: 6014.
• citrullination of cxcl10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation .Blood, Oct 2008; 112: 2648 - 2656.
• elr-negative cxc chemokine CXCL11 (ip-9/i-tac) facilitates dermal and epidermal maturation during wound repair .Am. J. Pathol., Sep 2008; 173: 643 - 652.
• matrix metalloproteinase processing of CXCL11/i-tac results in loss of chemoattractant activity and altered glycosaminoglycan binding .J. Biol. Chem., Jul 2008; 283: 19389 - 19399.
NCBI and Uniprot Product Information
NCBI Description
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Uniprot Description
CXCL11: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. Belongs to the intercrine alpha (chemokine CxC) family.
Protein type: Secreted; Motility/polarity/chemotaxis; Chemokine; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q21.2
Cellular Component: extracellular space; extracellular region
Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity
Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; immune response; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; positive regulation of cAMP metabolic process; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; signal transduction; chemotaxis; regulation of cell proliferation
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Product Notes
The ITAC cxcl11 (Catalog #AAA553011) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF. It is sometimes possible for the material contained within the vial of "ITAC (CXCL11), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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