Connexin 43 ELISA Kit | CX43 elisa kit
Connexin 43 Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014]
Uniprot Description
GJA1: an integral membrane protein of the connexin family, alpha-type (group II) subfamily. Hexamers of connexin-43 form connexons, which aggregate together to form gap junctions, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.
Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q22.31
Cellular Component: apical plasma membrane; connexin complex; contractile fiber; cytosol; early endosome; endoplasmic reticulum membrane; extracellular exosome; fascia adherens; focal adhesion; gap junction; Golgi apparatus; Golgi membrane; integral component of plasma membrane; intercalated disc; intermediate filament; lateral plasma membrane; lysosome; membrane raft; mitochondrial outer membrane; mitochondrion; multivesicular body; plasma membrane
Molecular Function: beta-tubulin binding; gap junction channel activity; gap junction channel activity involved in cardiac conduction electrical coupling; ion transmembrane transporter activity; PDZ domain binding; protein binding; receptor binding; SH3 domain binding; signal transducer activity
Biological Process: adult heart development; apoptosis; ATP transport; atrial cardiac muscle cell action potential; atrial ventricular junction remodeling; blood vessel morphogenesis; cell communication by chemical coupling; cell communication by electrical coupling; cell communication by electrical coupling involved in cardiac conduction; cell-cell signaling; cellular response to parathyroid hormone stimulus; cellular response to pH; chronic inflammatory response; decidualization; elevation of cytosolic calcium ion concentration; embryonic digit morphogenesis; endothelium development; epithelial cell maturation; gap junction assembly; heart development; heart looping; in utero embryonic development; lens development in camera-type eye; milk ejection reflex; muscle contraction; negative regulation of cardiac muscle cell proliferation; negative regulation of cell growth; negative regulation of DNA biosynthetic process; negative regulation of endothelial cell proliferation; negative regulation of gene expression; neuron migration; neuron projection morphogenesis; osteoblast differentiation; positive regulation of behavioral fear response; positive regulation of blood vessel diameter; positive regulation of cell communication by chemical coupling; positive regulation of gene expression; positive regulation of glomerular filtration; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of insulin secretion; positive regulation of osteoblast differentiation; positive regulation of protein catabolic process; positive regulation of striated muscle tissue development; positive regulation of vasoconstriction; protein oligomerization; regulation of bicellular tight junction assembly; regulation of bone mineralization; regulation of bone remodeling; regulation of calcium ion transport; regulation of transmembrane transporter activity; response to glucose stimulus; response to lipopolysaccharide; response to peptide hormone; response to retinoic acid; signal transduction; skeletal muscle tissue regeneration; transport; vascular transport
Disease: Atrioventricular Septal Defect 3; Craniometaphyseal Dysplasia, Autosomal Recessive; Erythrokeratodermia Variabilis Et Progressiva; Erythrokeratodermia Variabilis Et Progressiva 3; Hypoplastic Left Heart Syndrome 1; Oculodentodigital Dysplasia; Oculodentodigital Dysplasia, Autosomal Recessive; Palmoplantar Keratoderma And Congenital Alopecia 1; Syndactyly, Type Iii
Research Articles on CX43
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Product Notes
The Human, Mouse, Rat CX43 gja1 (Catalog #AAA9500141) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500141 ELISA Kit recognizes Human, Mouse, Rat CX43. It is sometimes possible for the material contained within the vial of "Connexin 43, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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