Rat CX3C chemokine receptor 1 ELISA Kit | Cx3cr1 elisa kit

Rat CX3C chemokine receptor 1 ELISA Kit

Cat. Num. AAA2886545

• Gene Names: Cx3cr1; Rbs11
• Reactivity: Rat
• Synonyms: CX3C chemokine receptor 1; Rat CX3C chemokine receptor 1 ELISA Kit; C-X3-C CKR-1; CX3CR1; Fractalkine receptor; RBS11; Cx3cr1; Rbs11; Cx3cr1 elisa kit

• Reactivity: Rat
• Sequence Length: 354

• Samples: Serum, Plasma, Tissue Homogenates, Cell Culture Supernates Or Other Biological Fluids.
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for Cx3cr1 elisa kit

Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 19424190
• NCBI GeneID: 171056
• NCBI Accession #: NP_598218.1
• NCBI GenBank Nucleotide #: NM_133534.1
• UniProt Accession #: P35411
• Molecular Weight: 40,327 Da
• NCBI Official Full Name: CX3C chemokine receptor 1
• NCBI Official Synonym Full Names: chemokine (C-X3-C motif) receptor 1
• NCBI Official Symbol: Cx3cr1
• NCBI Official Synonym Symbols: Rbs11
• NCBI Protein Information: CX3C chemokine receptor 1
• UniProt Protein Name: CX3C chemokine receptor 1
• Protein Family: CX3C chemokine receptor
• UniProt Gene Name: Cx3cr1
• UniProt Synonym Gene Names: Rbs11; C-X3-C CKR-1; CX3CR1
• UniProt Entry Name: CX3C1_RAT

NCBI Description

member of the rhodopsin family of G-protein coupled receptors; may act as a receptor for a chemokine peptide ligand [RGD, Feb 2006]

Uniprot Description

CX3CR1: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Defects in CX3CR1 are a cause of susceptibility to age- related macular degeneration type 12 (ARMD12). ARMD12 is a form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Receptor, cytokine; GPCR, family 1; Membrane protein, multi-pass; Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral

Cellular Component: integral to membrane; neuron projection; perinuclear region of cytoplasm

Molecular Function: C-X3-C chemokine receptor activity; hematopoietin/interferon-class (D200-domain) cytokine receptor activity

Biological Process: cell adhesion; cerebral cortex cell migration; cytokine and chemokine mediated signaling pathway; G-protein coupled receptor protein signaling pathway; macrophage chemotaxis; memory; microglial cell activation; microglial cell activation during immune response; negative regulation of angiogenesis; negative regulation of cell migration; negative regulation of chronic inflammatory response to non-antigenic stimulus; positive regulation of angiogenesis; positive regulation of neuroblast proliferation