Cathepsin G Recombinant Protein | Ctsg recombinant protein

Recombinant Mouse Cathepsin G

Cat. Num. AAA718416

• Gene Names: Ctsg; VSP; CatG
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cathepsin G; Recombinant Mouse Cathepsin G; Vimentin-specific protease; VSP; Ctsg recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 21-261; Full Length of Mature Protein
• Sequence: IIGGREARPHSYPYMAFLLIQSPEGLSACGGFLVREDFVLTAAHCLGSSINVTLGAHNIQMRERTQQLITVLRAIRHPDYNPQNIRNDIMLLQLRRRARRSGSVKPVALPQASKKLQPGDLCTVAGWGRVSQSRGTNVLQEVQLRVQMDQMCANRFQFYNSQTQICVGNPRERKSAFRGDSGGPLVCSNVAQGIVSYGSNNGNPPAVFTKIQSFMPWIKRTMRRFAPRYQRPANSLSQAQT

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for Ctsg recombinant protein

This vimentin-specific protease may regulate the reorganization of vimentin filaments, occurring during cell differentiation, movent and mitosis.

References

Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene.Heusel J.W., Scarpati E.M., Jenkins N.A., Gilbert D.J., Copeland N.G., Shapiro S.D., Ley T.J.Blood 81:1614-1623(1993) Kulmburg P., Baumruker T., Werner F.Huang R., Aveskogh M., Hellman L.T. Purification and characterization of a vimentin-specific protease in mouse myeloid leukemia cells. Regulation during differentiation and identity with cathepsin G.Nakamura N., Tsuru A., Hirayoshi K., Nagata K.Eur. J. Biochem. 205:947-954(1992)

NCBI and Uniprot Product Information

• NCBI GI #: 6681083
• NCBI GeneID: 13035
• NCBI Accession #: NP_031826.1
• NCBI GenBank Nucleotide #: NM_007800.2
• UniProt Accession #: P28293
• Molecular Weight: 42.9 kDa
• NCBI Official Full Name: cathepsin G preproprotein
• NCBI Official Synonym Full Names: cathepsin G
• NCBI Official Symbol: Ctsg
• NCBI Official Synonym Symbols: VSP; CatG
• NCBI Protein Information: cathepsin G
• UniProt Protein Name: Cathepsin G
• Protein Family: Cathepsin
• UniProt Gene Name: Ctsg
• UniProt Synonym Gene Names: VSP
• UniProt Entry Name: CATG_MOUSE

NCBI Description

This gene encodes a member of the peptidase S1 (chymotrypsin) family of serine endopeptidases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product appears to play a role in host defense, including inflammation and antigen processing. Homozygous knockout mice for this gene exhibit enhanced susceptibility to bacterial and fungal infection. [provided by RefSeq, Aug 2015]

Uniprot Description

CTSG: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride. Belongs to the peptidase S1 family.

Protein type: Motility/polarity/chemotaxis; EC 3.4.21.20; Protease

Cellular Component: cytoplasm; extracellular matrix; extracellular space; intermediate filament; intracellular membrane-bound organelle; membrane; nucleus; plasma membrane; secretory granule

Molecular Function: heparin binding; hydrolase activity; peptidase activity; serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: defense response to fungus; defense response to Gram-positive bacterium; immune response; positive regulation of immune response; protein amino acid phosphorylation; protein processing; proteolysis; response to lipopolysaccharide