Mouse Cathepsin B ELISA Kit | Ctsb elisa kit

Mouse Cathepsin B ELISA Kit

Cat. Num. AAA2885137

• Gene Names: Ctsb; CB
• Reactivity: Mouse
• Synonyms: Cathepsin B; Mouse Cathepsin B ELISA Kit; Cathepsin B1; Ctsb; 3.4.22.1; Ctsb elisa kit

• Reactivity: Mouse
• Sequence Length: 339

• Assay Type: Sandwich
• Detection Range: 0.78-50 ng/mL
• Sensitivity: 0.422 ng/mL
• Intra-Assay CV: <=7.6%
• Inter-Assay CV: <=9.7%
• Recovery: 102%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 6681079
• NCBI GeneID: 13030
• NCBI Accession #: NP_031824.1
• NCBI GenBank Nucleotide #: NM_007798.3
• UniProt Accession #: P10605; Q3UDW7
• Molecular Weight: 37,280 Da
• NCBI Official Full Name: cathepsin B preproprotein
• NCBI Official Synonym Full Names: cathepsin B
• NCBI Official Symbol: Ctsb
• NCBI Official Synonym Symbols: CB
• NCBI Protein Information: cathepsin B
• UniProt Protein Name: Cathepsin B
• Protein Family: Cathepsin
• UniProt Gene Name: Ctsb
• UniProt Entry Name: CATB_MOUSE

NCBI Description

This gene encodes a member of the peptidase C1 family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to generate the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. Homozygous knockout mice for this gene exhibit reduced pancreatic damage following induced pancreatitis and reduced hepatocyte apoptosis in a model of liver injury. Pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]

Uniprot Description

CTSB: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Belongs to the peptidase C1 family.

Protein type: Motility/polarity/chemotaxis; Autophagy; EC 3.4.22.1; Protease

Cellular Component: apical plasma membrane; caveola; cell surface; cytoplasm; external side of plasma membrane; extracellular region; extracellular space; intracellular membrane-bound organelle; lysosome; mitochondrion; nucleolus; perinuclear region of cytoplasm; sarcolemma

Molecular Function: collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; hydrolase activity; kininogen binding; peptidase activity; peptide binding; protein complex binding; protein self-association; proteoglycan binding

Biological Process: collagen catabolic process; decidualization; entry of virus into host cell; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of catalytic activity