Human CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 ELISA Kit | CTDP1 elisa kit
Human RNA polymerase II subunit A C-terminal domain phosphatase, CTDP1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Uniprot Description
CTDP1: a phospho-serine/threonine protein phosphatase which interacts with the carboxy-terminus of transcription initiation factor TFIIF-alpha, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. Its phosphorylation increases binding to TFIIF-alpha, affecting transcription elongation. Alternative splicing results in two different isoforms.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16; Transcription initiation complex
Chromosomal Location of Human Ortholog: 18q23
Cellular Component: nucleoplasm; spindle pole; centrosome; cytoplasm; spindle; spindle midzone; midbody; actin cytoskeleton
Molecular Function: DNA-directed RNA polymerase activity; CTD phosphatase activity
Biological Process: transcription from RNA polymerase II promoter; viral reproduction; cell division; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; gene expression; protein amino acid dephosphorylation; exit from mitosis
Disease: Congenital Cataracts, Facial Dysmorphism, And Neuropathy
Research Articles on CTDP1
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Product Notes
The Human CTDP1 ctdp1 (Catalog #AAA9339100) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9339100 ELISA Kit recognizes Human CTDP1. It is sometimes possible for the material contained within the vial of "CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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