CtBP1 recombinant protein

CtBP1, 1-440aa, Human, E Coli

Cat. Num. AAA203480

• Gene Names: CTBP1; BARS
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: CtBP1; 1-440aa; Human; E Coli; C-terminal-binding protein 1 isoform 1; BARS; C-terminal-binding protein 1 isoform 1 C terminal binding protein 1; CTBP; CTBP1; MGC104684.; CtBP1 recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 100mM NaCl, 10% glycerol
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHLLNKG LPLGVRPPIM NGPLHPRPLV ALLDGRDCTV EMPILKDVAT VAFCDAQSTQ EIHEKVLNEA VGALMYHTIT LTREDLEKFK ALRIIVRIGS GFDNIDIKSA GDLGIAVCNV PAASVEETAD STLCHILNLY RRATWLHQAL REGTRVQSVE QIREVASGAA RIRGETLGII GLGRVGQAVA LRAKAFGFNV LFYDPYLSDG VERALGLQRV STLQDLLFHS DCVTLHCGLN EHNHHLINDF TVKQMRQGAF LVNTARGGLV DEKALAQALK EGRIRGAALD VHESEPFSFS QGPLKDAPNL ICTPHAAWYS EQASIEMREE AAREIRRAIT GRIPDSLKNC VNKDHLTAAT HWASMDPAVV HPELNGAAYR YPPGVVGVAP TGIPAAVEGI VPSAMSLSHG LPPVAHPPHA PSPGQTVKPE ADRDHASDQL
• Sequence Length: 440

• Applicable Applications for CtBP1 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for CtBP1 recombinant protein

C-terminal-binding protein 1 isoform 1, also known as CtBP1, is expressed from embryo to adult. This protein binds to the C-terminus of adenovirus E1A. It is a cellular phosphoprotein that associates with various proteins and functions as a corepressor of transcription. Also, CtBP1 associates in complexes with histone deacetylases (HDAC), the G9a histone methyltransferase, and LSD1 histone demethylase illustrating its role in transcriptional repression. Recombinant human CtBP1 was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for CtBP1 recombinant protein

Cell Cycle

References

Izutsu K., et al. (2001) Blood. 97 (9):2815-22. ; Yu X., et al. (1998) J Biol Chem. 273:25388-25392. ;

NCBI and Uniprot Product Information

• NCBI GI #: 4557497
• NCBI GeneID: 1487
• NCBI Accession #: NP_001319
• NCBI GenBank Nucleotide #: NM_001328.2
• UniProt Accession #: Q13363; Q4W5N3; Q7Z2Q5
• Molecular Weight: 47.5 kDa (440aa), confirmed by MALDI-TOF.
• NCBI Official Full Name: C-terminal-binding protein 1 isoform 1
• NCBI Official Synonym Full Names: C-terminal binding protein 1
• NCBI Official Symbol: CTBP1
• NCBI Official Synonym Symbols: BARS
• NCBI Protein Information: C-terminal-binding protein 1
• UniProt Protein Name: C-terminal-binding protein 1
• UniProt Gene Name: CTBP1
• UniProt Synonym Gene Names: CTBP; CtBP1

NCBI Description

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Description

Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.