Cystatin SA / CST2 Recombinant Protein | CST2 recombinant protein

Recombinant Human Cystatin SA / CST2 Protein (His tag)

Cat. Num. AAA2545743

• Purity: > 98 % as determined by SDS-PAGE
• Synonyms: Cystatin SA / CST2; Recombinant Human Cystatin SA / CST2 Protein (His tag); CST2; MGC71924; CST2 recombinant protein

• Host: Human Cells
• Purity/Purification: > 98 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 141

• Application Notes: The secreted recombinant human CST2 consists of 132 amino acids and migrates as an approximately 16 kDa band in SDS-PAGE under reducing conditions as predicted.
• Predicted N Terminal: Trp 21
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for CST2 recombinant protein

Background: Cystatin-SA, also known as Cystatin-2, Cystatin-S5 and CST2, is a secreted protein which belongs to the cystatin family. Cystatin-2 / CST2 is expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). It is also expressed in submandibular gland and parotid gland. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The CST1, CST2, CST4, and CST5 are expressed in differential, tissue-specific patterns. Expression of CST2 and CST5 is restricted to the submandibular and parotid glands, while CST1 and CST4 are expressed in these tissues and in the lacrimal gland.

Description: A DNA sequence encoding the human CST2 (NP_001313.1) (Met 1-Ala 141) was fused with a polyhistidine tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 4503105
• NCBI GeneID: 1470
• NCBI Accession #: NP_001313.1
• NCBI GenBank Nucleotide #: NM_001322.2
• UniProt Accession #: P09228; Q9UCQ7
• Molecular Weight: 16,445 Da
• NCBI Official Full Name: cystatin-SA
• NCBI Official Synonym Full Names: cystatin SA
• NCBI Official Symbol: CST2
• NCBI Protein Information: cystatin-SA
• UniProt Protein Name: Cystatin-SA
• Protein Family: Cystatin
• UniProt Gene Name: CST2

NCBI Description

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma. [provided by RefSeq, Jul 2008]

Uniprot Description

CST2: Thiol protease inhibitor. Belongs to the cystatin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: extracellular space

Molecular Function: protease binding; protein binding

Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste