Cytotoxic and regulatory T-cell molecule (CRTAM) Recombinant Protein | CRTAM recombinant protein

Recombinant Human Cytotoxic and regulatory T-cell molecule (CRTAM)

• Gene Names: CRTAM; CD355
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cytotoxic and regulatory T-cell molecule (CRTAM); Recombinant Human Cytotoxic and regulatory T-cell molecule (CRTAM); Cytotoxic and regulatory T-cell molecule; Class-I MHC-restricted T-cell-associated molecule; CD_antigen=; CD355; CRTAM recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 18-287
• Sequence: SLT NHTETITVEE GQTLTLKCVT SLRKNSSLQW LTPSGFTIFL NEYPALKNSK YQLLHHSANQ LSITVPNVTL QDEGVYKCLH YSDSVSTKEV KVIVLATPFK PILEASVIRK QNGEEHVVLM CSTMRSKPPP QITWLLGNSM EVSGGTLHEF ETDGKKCNTT STLIIHTYGK NSTVDCIIRH RGLQGRKLVA PFRFEDLVTD EETASDALER NSLSSQDPQQ PTSTVSVTED SSTSEIDKEE KEQTTQDPDL TTEANPQYLG LARKKSG
• Sequence Length: 270

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 51593098
• NCBI GeneID: 56253
• NCBI Accession #: NP_062550.2
• NCBI GenBank Nucleotide #: NM_019604.2
• UniProt Accession #: O95727; Q59EI1; Q6IRX2
• Molecular Weight: 22,256 Da
• NCBI Official Full Name: cytotoxic and regulatory T-cell molecule
• NCBI Official Synonym Full Names: cytotoxic and regulatory T cell molecule
• NCBI Official Symbol: CRTAM
• NCBI Official Synonym Symbols: CD355
• NCBI Protein Information: cytotoxic and regulatory T-cell molecule; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; class-I MHC-restricted T-cell-associated molecule
• UniProt Protein Name: Cytotoxic and regulatory T-cell molecule
• Protein Family: Cytotoxic and regulatory T-cell molecule
• UniProt Gene Name: CRTAM
• UniProt Entry Name: CRTAM_HUMAN

NCBI Description

The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]

Uniprot Description

CRTAM: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 11q24.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: receptor binding

Biological Process: regulation of immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; detection of tumor cell; activated T cell proliferation; detection of stimulus; cell recognition; positive regulation of natural killer cell mediated cytotoxicity; T cell mediated cytotoxicity; positive regulation of cytokine secretion