Mouse CASP2 and RIPK1 domain containing adaptor with death domain ELISA Kit | CRADD elisa kit

Mouse Death domain-containing protein CRADD, CRADD ELISA Kit

Cat. Num. AAA9335163

• Gene Names: Cradd; RAIDD
• Reactivity: Mouse
• Synonyms: CASP2 and RIPK1 domain containing adaptor with death domain; Mouse Death domain-containing protein CRADD; CRADD ELISA Kit; Mouse Death domain-containing protein CRADD (CRADD) ELISA kit; MGC9163; RAIDD; RIP-associated ICH1/CED3-homologous protein with death domain; RIP-associated protein with a death domain; caspase and RIP adaptor with death domain; death adaptor molecule RAIDD; death; CRADD elisa kit

• Reactivity: Mouse

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 6753516
• NCBI GeneID: 12905
• NCBI Accession #: NP_034080.1
• NCBI GenBank Nucleotide #: NM_009950.2
• UniProt Accession #: O88843; Q9QUN0
• Molecular Weight: 22,656 Da
• NCBI Official Full Name: death domain-containing protein CRADD
• NCBI Official Synonym Full Names: CASP2 and RIPK1 domain containing adaptor with death domain
• NCBI Official Symbol: Cradd
• NCBI Official Synonym Symbols: RAIDD
• NCBI Protein Information: death domain-containing protein CRADD; caspase and RIP adapter with death domain; RIP-associated protein with a death domain; CASP2 and RIPK1 domain-containing adaptor with death domain
• UniProt Protein Name: Death domain-containing protein CRADD
• Protein Family: Death domain-containing protein
• UniProt Gene Name: Cradd
• UniProt Synonym Gene Names: Raidd
• UniProt Entry Name: CRADD_MOUSE

Uniprot Description

CRADD: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non- syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.

Protein type: Adaptor/scaffold; Apoptosis

Cellular Component: cytoplasm; intracellular; nucleus

Molecular Function: protein binding, bridging; protease binding

Biological Process: caspase activation; regulation of apoptosis; apoptosis; signal transduction; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest