CRABP2 recombinant protein

CRABP2, Recombinant, Human (CRABP-2, CRABPII, CRABP-II, Cellular Retinoic Acid-Binding Protein 2, RBP6, Retinoic Acid Binding ProCtein 6)

Cat. Num. AAA623365

• Gene Names: CRABP2; RBP6; CRABP-II
• Applications: ELISA
• Purity: > 95% by SDS PAGE
• Synonyms: CRABP2; Recombinant; Human (CRABP-2; CRABPII; CRABP-II; Cellular Retinoic Acid-Binding Protein 2; RBP6; Retinoic Acid Binding ProCtein 6); Anti -CRABP2; CRABP2 recombinant protein

• Purity/Purification: > 95% by SDS PAGE
• Form/Format: Supplied as a liquid in Liquid in 20 mM Tris pH 8.0, 20% glycerol.
• Sequence: MPNFSGNWKI IRSENFEELL KVLGVNVMLR KIAVAAASKP AVEIKQEGDT; FYIKTSTTVR TTEINFKVGE EFEEQTVDGR PCKSLVKWES ENKMVCEQKL; LKGEGPKTSW TRELTNDGEL ILTMTADDVV CTRVYVRE

• Applicable Applications for CRABP2 recombinant protein: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

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Related Product Information for CRABP2 recombinant protein

The cellular retinoic acid-binding protein II (CRABP-II) is involved in the conversion of vitamin A into its intracellular active form retinoic acid, which regulate the genes responsible for lipid metabolism and adipocyte differentiation. CRABP2 gene is located on chromosome 1q21-23 and this region has been linked with related disorders such as familial combined hyperlipidemia (FCHL) and type 2 diabetes mellitus.

Product Categories/Family for CRABP2 recombinant protein

Antibodies; Abs to Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 315013542
• NCBI GeneID: 1382
• NCBI Accession #: NP_001186652.1
• NCBI GenBank Nucleotide #: NM_001199723.1
• UniProt Accession #: P29373; Q6ICN6; B2R4Z8; D3DVC5; Q5SYZ4
• Molecular Weight: 15.6kD (138 aa)
• NCBI Official Full Name: cellular retinoic acid-binding protein 2
• NCBI Official Synonym Full Names: cellular retinoic acid binding protein 2
• NCBI Official Symbol: CRABP2
• NCBI Official Synonym Symbols: RBP6; CRABP-II
• NCBI Protein Information: cellular retinoic acid-binding protein 2; OTTHUMP00000038730; OTTHUMP00000038732; cellular retinoic acid-binding protein II
• UniProt Protein Name: Cellular retinoic acid-binding protein 2
• Protein Family: Cellular retinoic acid-binding protein
• UniProt Gene Name: CRABP2
• UniProt Entry Name: RABP2_HUMAN

NCBI Description

This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Uniprot Description

CRABP2: Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: nucleoplasm; endoplasmic reticulum; cytoplasm; cytosol

Molecular Function: retinoid binding; retinoic acid binding; transporter activity; retinol binding; retinal binding

Biological Process: embryonic forelimb morphogenesis; epidermis development; regulation of transcription, DNA-dependent; retinoic acid metabolic process; signal transduction; transmembrane transport