SFTPA1 / SFTPA2 Blocking Peptide | SFTPA1 blocking peptide
SFTPA1 / SFTPA2 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Description
SFTPA1B: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Genetic variations in SFTPA1 are a cause of susceptibility to pulmonary fibrosis idiopathic (IPF). Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease. Genetic variations in SFTPA1 are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS); also known as RDS in prematurity. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. The association between SFTPA1 alleles and respiratory distress syndrome in premature infants is dependent on a variation Ile to Thr at position 131 in SFTPB. Belongs to the SFTPA family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 10q22.3
Cellular Component: clathrin-coated endocytic vesicle; collagen; endoplasmic reticulum membrane; extracellular region; extracellular space; lamellar body; proteinaceous extracellular matrix
Molecular Function: carbohydrate binding; lipid transporter activity; protein binding
Biological Process: cellular protein metabolic process; lipid transport; respiratory gaseous exchange
Disease: Pulmonary Fibrosis, Idiopathic
Research Articles on SFTPA1
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Product Notes
The SFTPA1 sftpa1 (Catalog #AAA427391) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The SFTPA1 / SFTPA2 Immunizing Peptide reacts with Human, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-HLDEELQA TLHDFR. It is sometimes possible for the material contained within the vial of "SFTPA1 / SFTPA2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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