Rabbit anti-Human, Rat SFTPA1 Polyclonal Antibody | anti-SFTPA1 antibody

Anti-SFTPA1 antibody

Cat. Num. AAA175703

• Gene Names: SFTPA1; SPA; PSAP; PSPA; SP-A; SPA1; PSP-A; SFTP1; SP-A1; COLEC4; SFTPA1B
• Reactivity: Human, Rat
• Applications: Western Blot
• Purity: Immunogen affinity purified.
• Synonyms: SFTPA1; Polyclonal Antibody; Anti-SFTPA1 antibody; Pulmonary surfactant-associated protein A1(PSP-A/PSPA/SP-A/SP-A1); surfactant protein A1; 35 kDa pulmonary surfactant associated protein antibody; 35 kDa pulmonary surfactant-associated protein antibody; Alveolar proteinosis protein antibody; COLEC4 antibody; Collectin 4 antibody; Collectin-4 antibody; FLJ50593 antibody; FLJ51913 antibody; FLJ61144 antibody; FLJ77898; antibody; FLJ79095 antibody; FLJ99559 antibody; MGC133365 antibody; MGC198590 antibody; OTTHUMP00000019928 antibody; OTTHUMP00000019929 antibody; OTTHUMP00000019930 antibody; OTTHUMP00000019931 antibody; PSAP antibody; PSP A antibody; PSP-A antibody; PSPA antibody; pulmonary surfactant associated protein A1 antibody; Pulmonary surfactant-associated protein A1 antibody; SFTA1_HUMAN antibody; SFTP1 antibody; SFTPA1 antibody; SFTPA1B antibody; SP A antibody; SP A1 antibody; SP-A antibody; SP-A1 antibody; SPA antibody; SPA1 antibody; surfactant protein A1 variant AB'D' 6A2 antibody; surfactant protein A1 variant AB'D' 6A3 antibody; surfactant protein A1 variant AB'D' 6A4 antibody; surfactant protein A1 variant ACD' 6A2 antibody; surfactant protein A1 variant ACD' 6A3 antibody; surfactant protein A1 variant ACD' 6A4 antibody; surfactant protein A1 variant AD' 6A antibody; surfactant protein A1 variant AD' 6A2 antibody; surfactant protein A1 variant AD' 6A3 antibody; surfactant protein A1 variant AD' 6A4 antibody; surfactant protein A1B antibody; surfactant; pulmonary associated protein A1A antibody; pulmonary associated protein A1B antibody; anti-SFTPA1 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Liquid
• Concentration: 200ug/ml (varies by lot)
• Sequence Length: 248

• Applicable Applications for anti-SFTPA1 antibody: Western Blot (WB)
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human SFTPA1 (221-236aa KEQCVEMYTDGQWNDR), different from the rat sequence by two amino acids.
• Contents: Each vial contains 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

(Anti-SFTPA1 antibody, MBS175703, Western blottingLane 1: Rat Lung Tissue LysateLane 2: Rat Lung Tissue LysateLane 3: MK(55KD) )

Related Product Information for anti-SFTPA1 antibody

Description: Rabbit IgG polyclonal antibody for Pulmonary surfactant-associated protein A1(SFTPA1) detection. Tested with WB in Human, Rat.
Background: Surfactant protein A is an innate immune system collectin. The gene encoding SP-A map to mouse chromosome 14.1. Surfactant protein-A, which plays a role in innate host defense in the lung, is also expressed in the Eustachian tube. We report that the frequency of specific surfactant protein-A haplotypes and genotypes differs between children with recurrent otitis media compared with a control population.

NCBI and Uniprot Product Information

• NCBI GI #: 60416440
• NCBI GeneID: 653509
• UniProt Accession #: Q8IWL2; P07714; Q14DV4; Q5RIR5; Q5RIR7; A8K3T8; B7ZW50; E3VLD8; E3VLD9; E3VLE0; E3VLE1; G5E9J3
• Molecular Weight: 27,736 Da
• NCBI Official Full Name: Pulmonary surfactant-associated protein A1
• NCBI Official Synonym Full Names: surfactant protein A1
• NCBI Official Symbol: SFTPA1
• NCBI Official Synonym Symbols: SPA; PSAP; PSPA; SP-A; SPA1; PSP-A; SFTP1; SP-A1; COLEC4; SFTPA1B
• NCBI Protein Information: pulmonary surfactant-associated protein A1; collectin-4; surfactant protein A1B; alveolar proteinosis protein; surfactant protein A1 variant AD' 6A; surfactant protein A1 variant ACD' 6A; surfactant protein A1 variant AD' 6A2; surfactant protein A1 variant AD' 6A3; surfactant protein A1 variant AD' 6A4; surfactant protein A1 variant AB'D' 6A; surfactant protein A1 variant ACD' 6A2; surfactant protein A1 variant ACD' 6A3; surfactant protein A1 variant ACD' 6A4; surfactant protein A1 variant AB'D' 6A2; surfactant protein A1 variant AB'D' 6A3; surfactant protein A1 variant AB'D' 6A4; surfactant, pulmonary-associated protein A1A; surfactant, pulmonary-associated protein A1B; 35 kDa pulmonary surfactant-associated protein
• UniProt Protein Name: Pulmonary surfactant-associated protein A1
• Protein Family: Pulmonary surfactant-associated protein
• UniProt Gene Name: SFTPA1
• UniProt Synonym Gene Names: COLEC4; PSAP; SFTP1; SFTPA; SFTPA1B; PSP-A; PSPA; SP-A; SP-A1
• UniProt Entry Name: SFTA1_HUMAN

NCBI Description

This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Uniprot Description

SFTPA1B: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Genetic variations in SFTPA1 are a cause of susceptibility to pulmonary fibrosis idiopathic (IPF). Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease. Genetic variations in SFTPA1 are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS); also known as RDS in prematurity. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. The association between SFTPA1 alleles and respiratory distress syndrome in premature infants is dependent on a variation Ile to Thr at position 131 in SFTPB. Belongs to the SFTPA family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q22.3

Cellular Component: extracellular space; proteinaceous extracellular matrix; collagen; extracellular region

Molecular Function: lipid transporter activity; carbohydrate binding

Biological Process: respiratory gaseous exchange; lipid transport

Disease: Pulmonary Fibrosis, Idiopathic