VMAT2 / SLC18A2 Blocking Peptide | SLC18A2 blocking peptide
VMAT2 / SLC18A2 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011]
Uniprot Description
SLC18A2: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. Belongs to the major facilitator superfamily. Vesicular transporter family.
Protein type: Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 10q25
Cellular Component: cell soma; integral to plasma membrane; membrane; plasma membrane; synaptic vesicle; synaptic vesicle membrane; terminal button
Molecular Function: amine transmembrane transporter activity; drug binding; enzyme binding; heat shock protein binding; monoamine transmembrane transporter activity; serotonin transmembrane transporter activity
Biological Process: aging; dopamine transport; endocytic recycling; glucose homeostasis; insulin secretion; locomotory behavior; monoamine transport; negative regulation of neurotransmitter transport; neurotransmitter secretion; post-embryonic development; response to amphetamine; response to cocaine; response to corticosterone stimulus; response to herbicide; response to starvation; response to zinc ion; sequestering of neurotransmitter; serotonin transport; synaptic transmission; synaptic vesicle amine transport; transmembrane transport
Research Articles on SLC18A2
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Product Notes
The SLC18A2 slc18a2 (Catalog #AAA425488) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The VMAT2 / SLC18A2 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Pig, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-SYPIGEDE ESESD. It is sometimes possible for the material contained within the vial of "VMAT2 / SLC18A2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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