Coatomer Protein Complex Subunit Epsilon Recombinant Protein | COPE recombinant protein

Recombinant Human Coatomer Protein Complex Subunit Epsilon

Cat. Num. AAA140705

• Gene Names: COPE; epsilon-COP
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Coatomer Protein Complex Subunit Epsilon; Recombinant Human Coatomer Protein Complex Subunit Epsilon; COPE Human; Coatomer Protein Complex Subunit Epsilon Human Recombinant; Coatomer Protein Complex; Subunit Epsilon; Epsilon-Coat Protein; Epsilon-COP; Coatomer Epsilon Subunit; Coatomer Subunit Epsilon; Epsilon Coat Protein; Coatomer subunit epsilon; COPE recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: COPE protein solution (0.25 mg/ml) containing Phosphate buffered saline (pH7.4), 20% glycerol and 1mM DTT.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAPPAPG PASGGSGEVD ELFDVKNAFY IGSYQQCINE AQRVKLSSPERDVERDVFLY RAYLAQRKFG VVLDEIKPSS APELQAVRMF ADYLAHESRR DSIVAELDRE MSRSVDVTNTTFLLMAASIY LHDQNPDAAL RALHQGDSLE CTAMTVQILLKLDRLDLARK ELKRMQDLDE DATLTQLATA WVSLATGGEK LQDAYYIFQEMADKCSPTLL LLNGQAACHM AQGRWEAAEG LLQEALDKDS GYPETLVNLI VLSQHLGKPP EVTNRYLSQLKDAHRSHPFI KEYQAKENDF DRLVLQYAPS A
• Sequence Length: 308

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Related Product Information for COPE recombinant protein

COPE Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 331 amino acids (1-308 a.a) and having a molecular mass of 36.9kDa. COPE is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Categories/Family for COPE recombinant protein

Recombinant & Natural Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 31542319
• NCBI GeneID: 11316
• NCBI Accession #: NP_009194.2
• NCBI GenBank Nucleotide #: NM_007263.3
• UniProt Accession #: O14579; O76097; Q6IBB8; Q9UGP6; A6NE29; A6NKA3
• Molecular Weight: 28,773 Da
• NCBI Official Full Name: coatomer subunit epsilon isoform a
• NCBI Official Synonym Full Names: coatomer protein complex subunit epsilon
• NCBI Official Symbol: COPE
• NCBI Official Synonym Symbols: epsilon-COP
• NCBI Protein Information: coatomer subunit epsilon
• UniProt Protein Name: Coatomer subunit epsilon
• Protein Family: Coatomer
• UniProt Gene Name: COPE
• UniProt Synonym Gene Names: Epsilon-COP
• UniProt Entry Name: COPE_HUMAN

Uniprot Description

COPE: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Belongs to the COPE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: COPI vesicle coat; cytosol; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; nucleoplasm; transport vesicle

Molecular Function: protein binding

Biological Process: ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to ER