Collagen alpha-1 (III) Chain/COL3A1 Recombinant Protein | COL3A1 recombinant protein

Recombinant Mouse Collagen alpha-1 (III) Chain/COL3A1 Protein (C-6His)

Cat. Num. AAA2553467

• Gene Names: Col3a1; Tsk2; Tsk-2; Col3a-1; AW550625
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Collagen alpha-1 (III) Chain/COL3A1; Recombinant Mouse Collagen alpha-1 (III) Chain/COL3A1 Protein (C-6His); Collagen alpha-1(III) chain; Col3a1; COL3A1 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH4.5.
• Sequence Positions: Gln155-Gly1219
• Sequence Length: 1464

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.

Related Product Information for COL3A1 recombinant protein

Collagen alpha-1(III) chain(Col3a1) is a secreted protein and belongs to the fibrillar collagen family.It contains 1 fibrillar collagen NC1 domain and 1 VWFC domain. Collagen alpha-1(III) chain is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I collagen. The COL3A1 gene produces the components of type III collagen, called pro-alpha1(III) chains. Three copies of this chain combine to make a molecule of type III procollagen. These triple-stranded, rope-like procollagen molecules must be processed by enzymes outside the cell to remove extra protein segments from their ends. Once these molecules are processed, the collagen molecules arrange themselves into long, thin fibrils. Within these fibrils, the individual collagen molecules are cross-linked to one another. These cross-links result in the formation of very strong mature type III collagen fibrils, which are found in the spaces around cells.

NCBI and Uniprot Product Information

• NCBI GI #: 226423933
• NCBI GeneID: 12825
• NCBI Accession #: NP_034060.2
• NCBI GenBank Nucleotide #: NM_009930.2
• UniProt Accession #: P08121; Q61429; Q9CRN7
• Molecular Weight: Molecular Mass: 96.6 kDa; Actual Protein Molecular Mass: 130 kDa
• NCBI Official Full Name: collagen alpha-1(III) chain preproprotein
• NCBI Official Synonym Full Names: collagen, type III, alpha 1
• NCBI Official Symbol: Col3a1
• NCBI Official Synonym Symbols: Tsk2; Tsk-2; Col3a-1; AW550625
• NCBI Protein Information: collagen alpha-1(III) chain
• UniProt Protein Name: Collagen alpha-1(III) chain
• Protein Family: Collagen
• UniProt Gene Name: Col3a1

NCBI Description

This gene encodes the alpha-1 subunit of the fibril-forming type III collagen found in bone, cartilage, dentin, tendon, bone marrow stroma and other connective tissue. The encoded protein forms homotrimeric type III procollagen that undergoes proteolytic processing during fibril formation. A majority of mice lacking the encoded protein die within two days of birth but about 5% of the animals survive to adulthood. The surviving mice exhibit severe cortical malformation and experience significantly shorter lifespan. The mutant mouse named "tight skin 2" exhibiting systemic sclerosis phenotype was found to harbor a missense point mutation in this gene. A pseudogene of this gene has been defined on chromosome 8. [provided by RefSeq, Nov 2015]

Uniprot Description

Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.