Rat Collagen alpha-1 (III) chain ELISA Kit | Col3a1 elisa kit

Rat Collagen alpha-1 (III) chain ELISA Kit

Cat. Num. AAA9425297

• Reactivity: Rat
• Synonyms: Collagen alpha-1 (III) chain; Rat Collagen alpha-1 (III) chain ELISA Kit; Col3a1; Col3a1 elisa kit

• Reactivity: Rat

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Detection Range: 0.156-10 ng/mL
• Assay Time: 3-5h
• Sample Volume: 100T
• Detection Wavelength: 450 nm
• Preparation and Storage: Store at 4 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 56711254
• NCBI GeneID: 84032
• NCBI Accession #: NP_114474.1
• NCBI GenBank Nucleotide #: NM_032085.1
• UniProt Accession #: P13941; O70604; Q5PQT6
• Molecular Weight: 138,936 Da
• NCBI Official Full Name: collagen alpha-1(III) chain
• NCBI Official Synonym Full Names: collagen type III alpha 1 chain
• NCBI Official Symbol: Col3a1
• NCBI Protein Information: collagen alpha-1(III) chain
• UniProt Protein Name: Collagen alpha-1(III) chain
• Protein Family: Collagen
• UniProt Gene Name: Col3a1

NCBI Description

may be involved in craniofacial development [RGD, Feb 2006]

Uniprot Description

CO3A1: Collagen type III occurs in most soft connective tissues along with type I collagen. Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3); also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity. Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type 4 (EDS4). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS4 is the most severe form of the disease. It is characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas. Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA). AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells. Belongs to the fibrillar collagen family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: collagen; collagen type III; extracellular matrix; extracellular space; proteinaceous extracellular matrix

Molecular Function: extracellular matrix structural constituent; integrin binding; platelet-derived growth factor binding; protease binding; SMAD binding

Biological Process: aging; blood vessel development; cell-matrix adhesion; cerebral cortex development; collagen fibril organization; gut development; heart development; integrin-mediated signaling pathway; negative regulation of immune response; peptide cross-linking; positive regulation of Rho protein signal transduction; response to cytokine stimulus; response to mechanical stimulus; response to radiation; skeletal development; skin development; transforming growth factor beta receptor signaling pathway; wound healing