SDS-PAGE
CNDP2 / CPGL / PEPA recombinant protein
Recombinant Human CNDP2 / CPGL / PEPA Protein (His tag)
Gene Names
CNDP2; CN2; CPGL; PEPA; HsT2298; HEL-S-13
Purity
> 94 % as determined by SDS-PAGE
Synonyms
CNDP2 / CPGL / PEPA; Recombinant Human CNDP2 / CPGL / PEPA Protein (His tag); CN2; CPGL; FLJ10830; HsT2298; PEPA; CNDP2 / CPGL / PEPA recombinant protein
Host
Baculovirus-Insect Cells
Purity/Purification
> 94 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile 50mM Tris, 100mM NaCl, 0.5mM PMSF, pH 8.0
Sequence Length
475
Application Notes
The secreted recombinant human CNDP2 consists of 485 amino acids and predicts a molecular mass of 54.2 kDa as estimated in SDS-PAGE under reducing conditions.
Predicted N Terminal
Met 1
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for CNDP2 / CPGL / PEPA recombinant protein
Background: Mouse cytosolic non-specific dipeptidase, also known as CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2 and CN2, is a cytoplasm protein which belongs to the peptidase M20A family. CNDP2 / CPGL is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. CNDP2 / CPGL hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. It may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Isoform 1 of CNDP2 / CPGL is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 of CNDP2 / CPGL is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. CNDP2 / CPGL is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis.
Description: A DNA sequence encoding the human CNDP2 (CAC69883.1) (Met 1-Asp 475) was expressed, fused with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the human CNDP2 (CAC69883.1) (Met 1-Asp 475) was expressed, fused with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
43,833 Da
NCBI Official Full Name
glutamate carboxypeptidase
NCBI Official Synonym Full Names
CNDP dipeptidase 2 (metallopeptidase M20 family)
NCBI Official Symbol
CNDP2
NCBI Official Synonym Symbols
CN2; CPGL; PEPA; HsT2298; HEL-S-13
NCBI Protein Information
cytosolic non-specific dipeptidase
UniProt Protein Name
Cytosolic non-specific dipeptidase
UniProt Gene Name
CNDP2
NCBI Description
CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]
Uniprot Description
CNDP2: Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Belongs to the peptidase M20A family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.13.18; Protease
Chromosomal Location of Human Ortholog: 18q22.3
Cellular Component: cytoplasm; cytosol; nucleoplasm
Molecular Function: carboxypeptidase activity; zinc ion binding
Biological Process: glutathione biosynthetic process; peptide catabolic process; sulfur amino acid metabolic process
Research Articles on CNDP2 / CPGL / PEPA
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Product Notes
The CNDP2 / CPGL / PEPA cndp2 (Catalog #AAA2546462) is a Recombinant Protein produced from Baculovirus-Insect Cells and is intended for research purposes only. The product is available for immediate purchase. The secreted recombinant human CNDP2 consists of 485 amino acids and predicts a molecular mass of 54.2 kDa as estimated in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the CNDP2 / CPGL / PEPA cndp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CNDP2 / CPGL / PEPA, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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