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Chemokine-like receptor 1 (Cmklr1) Recombinant Protein | Cmklr1 recombinant protein

Recombinant Mouse Chemokine-like receptor 1 (Cmklr1)

Gene Names
Cmklr1; DEZ; Gpcr27; ChemR23; mcmklr1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Chemokine-like receptor 1 (Cmklr1); Recombinant Mouse Chemokine-like receptor 1 (Cmklr1); Cmklr1 recombinant protein
Ordering
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-371
Sequence
MEYDAYNDSGIYDDEYSDGFGYFVDLEEASPWEAKVAPVFLVVIYSLVCFLGLLGNGLVIVIATFKMKKTVNTVWFVNLAVADFLFNIFLPMHITYAAMDYHWVFGKAMCKISNFLLSHNMYTSVFLLTVISFDRCISVLLPVWSQNHRSIRLAYMTCSAVWVLAFFLSSPSLVFRDTANIHGKITCFNNFSLAAPESSPHPAHSQVVSTGYSRHVAVTVTRFLCGFLIPVFIITACYLTIVFKLQRNRLAKNKKPFKIIITIIITFFLCWCPYHTLYLLELHHTAVPSSVFSLGLPLATAVAIANSCMNPILYVFMGHDFRKFKVALFSRLANALSEDTGPSSYPSHRSFTKMSSLNEKASVNEKETSTL
Sequence Length
371
Species
Mus musculus (Mouse)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Related Product Information for Cmklr1 recombinant protein
Cmklr1; Dez, Gpcr27

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
41,815 Da
NCBI Official Full Name
chemokine-like receptor 1
NCBI Official Synonym Full Names
chemokine-like receptor 1
NCBI Official Symbol
Cmklr1
NCBI Official Synonym Symbols
DEZ; Gpcr27; ChemR23; mcmklr1
NCBI Protein Information
chemokine-like receptor 1; chemerin receptor; chemokine receptor-like 1; G-protein coupled receptor 27; G-protein coupled receptor DEZ
UniProt Protein Name
Chemokine-like receptor 1
UniProt Gene Name
Cmklr1
UniProt Synonym Gene Names
Dez; Gpcr27
UniProt Entry Name
CML1_MOUSE

Uniprot Description

Function: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B

By similarity. Ref.3 Ref.4

Subcellular location: Cell membrane; Multi-pass membrane protein Ref.4.

Tissue specificity: Highly expressed in immature plasmacytoid dendritic cells (DCs) and at lower levels in myeloid DCs, macrophages, and NK cells. Expressed on macrophages isolated from differents tissues, including peritoneal cavities, pleural cavities and spleen. Ref.4 Ref.5

Developmental stage: Expressed during bone development and in adult parathyroid glands. Expressed at day E11 in the caudal part of the tongue and the umbilical cord and the expression in the tongue was maintained throughout adulthood. Expression increases in bone and cartilaginous forming zones of embryo up to stage E14.5 and at E16.5 expression is seen in the lung. Ref.1

Induction: Down-regulated by bacterial lipopolysaccharide (LPS), IFN-alpha and TNF on macrophages. Ref.4

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

Research Articles on Cmklr1

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Product Notes

The Cmklr1 cmklr1 (Catalog #AAA718017) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-371. The amino acid sequence is listed below: MEYDAYNDSG IYDDEYSDGF GYFVDLEEAS PWEAKVAPVF LVVIYSLVCF LGLLGNGLVI VIATFKMKKT VNTVWFVNLA VADFLFNIFL PMHITYAAMD YHWVFGKAMC KISNFLLSHN MYTSVFLLTV ISFDRCISVL LPVWSQNHRS IRLAYMTCSA VWVLAFFLSS PSLVFRDTAN IHGKITCFNN FSLAAPESSP HPAHSQVVST GYSRHVAVTV TRFLCGFLIP VFIITACYLT IVFKLQRNRL AKNKKPFKII ITIIITFFLC WCPYHTLYLL ELHHTAVPSS VFSLGLPLAT AVAIANSCMN PILYVFMGHD FRKFKVALFS RLANALSEDT GPSSYPSHRS FTKMSSLNEK ASVNEKETST L. It is sometimes possible for the material contained within the vial of "Chemokine-like receptor 1 (Cmklr1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.
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