Chemokine-like receptor 1 (Cmklr1) Recombinant Protein | Cmklr1 recombinant protein
Recombinant Mouse Chemokine-like receptor 1 (Cmklr1)
NCBI and Uniprot Product Information
Uniprot Description
Function: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B
By similarity. Ref.3 Ref.4
Subcellular location: Cell membrane; Multi-pass membrane protein Ref.4.
Tissue specificity: Highly expressed in immature plasmacytoid dendritic cells (DCs) and at lower levels in myeloid DCs, macrophages, and NK cells. Expressed on macrophages isolated from differents tissues, including peritoneal cavities, pleural cavities and spleen. Ref.4 Ref.5
Developmental stage: Expressed during bone development and in adult parathyroid glands. Expressed at day E11 in the caudal part of the tongue and the umbilical cord and the expression in the tongue was maintained throughout adulthood. Expression increases in bone and cartilaginous forming zones of embryo up to stage E14.5 and at E16.5 expression is seen in the lung. Ref.1
Induction: Down-regulated by bacterial lipopolysaccharide (LPS), IFN-alpha and TNF on macrophages. Ref.4
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.