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ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (CLPX) Recombinant Protein | CLPX recombinant protein

Recombinant Human ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (CLPX)

Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
ATP-dependent Clp protease ATP-binding subunit clpX-like; mitochondrial (CLPX); Recombinant Human ATP-dependent Clp protease ATP-binding subunit clpX-like; CLPX recombinant protein
Ordering
For Research Use Only!
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
57-633, Full length protein
Sequence
FTETPAYFASKDGISKDGSGDGNKKSASEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEVEKQTSLTPRELEIRRREDEYRFTKLLQIAGISPHGNALGASMQQQVNQQIPQEKRGGEVLDSSHDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNILFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPTKESSEEEYDSGVEEEGWPRQADAANS
Sequence Length
577
Species
Human
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
69,224 Da
NCBI Official Full Name
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
NCBI Official Synonym Full Names
caseinolytic mitochondrial matrix peptidase chaperone subunit
NCBI Official Symbol
CLPX
NCBI Protein Information
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
UniProt Protein Name
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
UniProt Gene Name
CLPX

NCBI Description

The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Description

ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Important for efficient erythropoiesis through upregulation of heme biosynthesis (PubMed:25957689).

Research Articles on CLPX

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Product Notes

The CLPX clpx (Catalog #AAA1120976) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 57-633, Full length protein. The amino acid sequence is listed below: FTETPAYFAS KDGISKDGSG DGNKKSASEG SSKKSGSGNS GKGGNQLRCP KCGDLCTHVE TFVSSTRFVK CEKCHHFFVV LSEADSKKSI IKEPESAAEA VKLAFQQKPP PPPKKIYNYL DKYVVGQSFA KKVLSVAVYN HYKRIYNNIP ANLRQQAEVE KQTSLTPREL EIRRREDEYR FTKLLQIAGI SPHGNALGAS MQQQVNQQIP QEKRGGEVLD SSHDDIKLEK SNILLLGPTG SGKTLLAQTL AKCLDVPFAI CDCTTLTQAG YVGEDIESVI AKLLQDANYN VEKAQQGIVF LDEVDKIGSV PGIHQLRDVG GEGVQQGLLK LLEGTIVNVP EKNSRKLRGE TVQVDTTNIL FVASGAFNGL DRIISRRKNE KYLGFGTPSN LGKGRRAAAA ADLANRSGES NTHQDIEEKD RLLRHVEARD LIEFGMIPEF VGRLPVVVPL HSLDEKTLVQ ILTEPRNAVI PQYQALFSMD KCELNVTEDA LKAIARLALE RKTGARGLRS IMEKLLLEPM FEVPNSDIVC VEVDKEVVEG KKEPGYIRAP TKESSEEEYD SGVEEEGWPR QADAANS. It is sometimes possible for the material contained within the vial of "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (CLPX), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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