Rabbit anti-Human, Mouse FE65L1 / APBB2 Polyclonal Antibody | anti-FE65L1 antibody

Rabbit Polyclonal (IgG) to Human FE65L1 / APBB2

Cat. Num. AAA244352

• Gene Names: APBB2; FE65L; FE65L1
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: FE65L1 / APBB2; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human FE65L1 / APBB2; Anti-FE65L1 / APBB2 Antibody (aa471-520) IHC-plus; APBB2; Fe65-like 1; FE65L1; Fe65-like; FE65L; Protein Fe65-like 1; Human FE65L1; anti-FE65L1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: APBB2 Antibody detects endogenous levels of total APBB2 protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 758

• Applicable Applications for anti-FE65L1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:40000), IHC-P (10 ug/ml), WB (1:500 - 1:1000)
• Target Species: Human
• Immunogen Description: Synthetic peptide from human APBB2 (aa471-520).
• Immunogen: FE65L1 / APBB2 antibody was raised against synthetic peptide from human APBB2 (aa471-520).
• Antigen Modification: aa471-520
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC)

(Anti-APBB2 antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunohistochemistry (IHC)

(Anti-APBB2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Western Blot (WB)

(Western blot of extracts from LOVO cells, using APBB2 Antibody. The lane on the right is treated with the synthesized peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 260593731
• NCBI GeneID: 323
• NCBI Accession #: NP_001159522.1
• NCBI GenBank Nucleotide #: NM_001166050.1
• UniProt Accession #: Q92870; Q8IUI6; B4DSL4; E9PG87
• Molecular Weight: 83,445 Da
• NCBI Official Full Name: amyloid beta A4 protein-binding family B member 2 isoform b
• NCBI Official Synonym Full Names: amyloid beta (A4) precursor protein-binding, family B, member 2
• NCBI Official Symbol: APBB2
• NCBI Official Synonym Symbols: FE65L; FE65L1
• NCBI Protein Information: amyloid beta A4 precursor protein-binding family B member 2; Fe65-like 1; protein Fe65-like 1
• UniProt Protein Name: Amyloid beta A4 precursor protein-binding family B member 2
• UniProt Gene Name: APBB2
• UniProt Synonym Gene Names: FE65L; FE65L1
• UniProt Entry Name: APBB2_HUMAN

NCBI Description

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Uniprot Description

APBB2: May modulate the internalization of beta-amyloid precursor protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 4p13

Cellular Component: growth cone; membrane; lamellipodium; cytoplasm; synapse; nucleus

Molecular Function: protein binding; beta-amyloid binding; transcription factor binding

Biological Process: axon guidance; extracellular matrix organization and biogenesis; regulation of transcription, DNA-dependent; positive regulation of apoptosis; neuron migration; negative regulation of cell growth; cell cycle arrest; negative regulation of apoptosis

Disease: Alzheimer Disease