CLEC10A/CD301 recombinant protein

Recombinant Human CLEC10A/CD301 Protein (C-6His)

Cat. Num. AAA2552506

• Gene Names: CLEC10A; HML; MGL; HML2; CD301; CLECSF13; CLECSF14
• Purity: >90% as determined by reducing SDS-PAGE.
• Synonyms: CLEC10A/CD301; Recombinant Human CLEC10A/CD301 Protein (C-6His); C-Type Lectin Domain Family 10 Member A; C-Type Lectin Superfamily Member 14; Macrophage Lectin 2; CD301; CLEC10A; CLECSF13; CLECSF14; HML; CLEC10A/CD301 recombinant protein

• Host: Human Cells
• Purity/Purification: >90% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Positions: Gln61-His316
• Sequence Length: 292

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for CLEC10A/CD301 recombinant protein

C-Type Lectin Domain Family 10 Member A (CLEC10A) is a type II transmembrane C-type lectin that is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. CLEC10A/MGL binds and internalizes molecules with terminal nonsialylated GalNAc carbohydrates such as the Tn carcinoma antigen. CLEC10A/MGL also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity. It constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. CLEC10A is thought to participate in the recognition of molecules from both altered self and pathogens due to its monosaccharide specificity for Gal and N-acetylgalactosamine (GalNAc). Human and rat carry a single gene for CLEC10A/MGL, while mouse has two closely related MGL1 and MGL2 genes.

NCBI and Uniprot Product Information

• NCBI GI #: 53832016
• NCBI GeneID: 10462
• NCBI Accession #: NP_006335.2
• NCBI GenBank Nucleotide #: NM_006344.3
• UniProt Accession #: Q8IUN9; Q14538; Q6PIW3; A8K8J8
• Molecular Weight: Molecular Mass: 29.8 kDa; Actual Protein Molecular Mass: 40 kDa
• NCBI Official Full Name: C-type lectin domain family 10 member A isoform 2
• NCBI Official Synonym Full Names: C-type lectin domain containing 10A
• NCBI Official Symbol: CLEC10A
• NCBI Official Synonym Symbols: HML; MGL; HML2; CD301; CLECSF13; CLECSF14
• NCBI Protein Information: C-type lectin domain family 10 member A
• UniProt Protein Name: C-type lectin domain family 10 member A
• UniProt Gene Name: CLEC10A
• UniProt Synonym Gene Names: CLECSF13; CLECSF14; HML

NCBI Description

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.