H (+)/Cl (-) exchange transporter 3 (CLCN3) Recombinant Protein | CLCN3 recombinant protein
Recombinant Human H (+)/Cl (-) exchange transporter 3 (CLCN3)
Gene Names
CLCN3; CLC3; ClC-3
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
H (+)/Cl (-) exchange transporter 3 (CLCN3); Recombinant Human H (+)/Cl (-) exchange transporter 3 (CLCN3); Chloride channel protein 3Chloride transporter ClC-3; CLCN3 recombinant protein
Host
Cell Free Expression
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Liquid containing glycerol
Sequence Positions
1-818aa, Full Length
Sequence
MASMTGGQQMGRDPMESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN
Application Notes
This is a recombinant transmembrane protein expressed in a cell-free expression system.
Species
Human
Tag
C-terminal 6xHis-tagged
Function
Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.MiscellaneousThe CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity).
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 degree C/-80 degree C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Product Categories/Family for CLCN3 recombinant protein
References
"ClC-3B, a novel ClC-3 splicing variant that interacts with EBP50 and facilitates expression of CFTR-regulated ORCC."Ogura T., Furukawa T., Toyozaki T., Yamada K., Zheng Y.-J., Katayama Y., Nakaya H., Inagaki N.FASEB J. 16:863-865 (2002)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
818
NCBI Official Full Name
H(+)/Cl(-) exchange transporter 3
NCBI Official Synonym Full Names
chloride channel, voltage-sensitive 3
NCBI Official Symbol
CLCN3
NCBI Official Synonym Symbols
CLC3; ClC-3
NCBI Protein Information
H(+)/Cl(-) exchange transporter 3; H(+)/Cl(-) exchange transporter 3; chloride channel 3; chloride channel protein 3; chloride transporter ClC-3
UniProt Protein Name
H(+)/Cl(-) exchange transporter 3
Protein Family
UniProt Gene Name
CLCN3
UniProt Synonym Gene Names
ClC-3
UniProt Entry Name
CLCN3_HUMAN
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Product Notes
The CLCN3 clcn3 (Catalog #AAA7137051) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-818aa, Full Length. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the CLCN3 clcn3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MASMTGGQQM GRDPMESEQL FHRGYYRNSY NSITSASSDE ELLDGAGVIM DFQTSEDDNL LDGDTAVGTH YTMTNGGSIN SSTHLLDLLD EPIPGVGTYD DFHTIDWVRE KCKDRERHRR INSKKKESAW EMTKSLYDAW SGWLVVTLTG LASGALAGLI DIAADWMTDL KEGICLSALW YNHEQCCWGS NETTFEERDK CPQWKTWAEL IIGQAEGPGS YIMNYIMYIF WALSFAFLAV SLVKVFAPYA CGSGIPEIKT ILSGFIIRGY LGKWTLMIKT ITLVLAVASG LSLGKEGPLV HVACCCGNIF SYLFPKYSTN EAKKREVLSA ASAAGVSVAF GAPIGGVLFS LEEVSYYFPL KTLWRSFFAA LVAAFVLRSI NPFGNSRLVL FYVEYHTPWY LFELFPFILL GVFGGLWGAF FIRANIAWCR RRKSTKFGKY PVLEVIIVAA ITAVIAFPNP YTRLNTSELI KELFTDCGPL ESSSLCDYRN DMNASKIVDD IPDRPAGIGV YSAIWQLCLA LIFKIIMTVF TFGIKVPSGL FIPSMAIGAI AGRIVGIAVE QLAYYHHDWF IFKEWCEVGA DCITPGLYAM VGAAACLGGV TRMTVSLVVI VFELTGGLEY IVPLMAAVMT SKWVGDAFGR EGIYEAHIRL NGYPFLDAKE EFTHTTLAAD VMRPRRNDPP LAVLTQDNMT VDDIENMINE TSYNGFPVIM SKESQRLVGF ALRRDLTIAI ESARKKQEGI VGSSRVCFAQ HTPSLPAESP RPLKLRSILD MSPFTVTDHT PMEIVVDIFR KLGLRQCLVT HNGRLLGIIT KKDILRHMAQ TANQDPASIM FN. It is sometimes possible for the material contained within the vial of "H (+)/Cl (-) exchange transporter 3 (CLCN3), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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