Sequence Information
Cardiotrophin Like Cytokine Factor 1 (CLCF1) Recombinant Protein | CLCF1 recombinant protein
Recombinant Cardiotrophin Like Cytokine Factor 1 (CLCF1)
Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Sequence Information
Sequence Information
Identification
(Gene Sequencing (extract))
Identification
(Gene Sequencing (extract))
SDS-PAGE
SDS-PAGE
NCBI and Uniprot Product Information
Accurate Molecular Mass: 26kDa as determined by SDS-PAGE reducing conditions.
Uniprot Description
CLCF1: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Cytokine; Secreted, signal peptide; Apoptosis
Cellular Component: extracellular space; extracellular region; intracellular
Molecular Function: protein binding; protein heterodimerization activity; cytokine activity; ciliary neurotrophic factor receptor binding; receptor binding
Biological Process: positive regulation of T-helper 2 type immune response; regulation of protein kinase B signaling cascade; JAK-STAT cascade; positive regulation of isotype switching to IgE isotypes; positive regulation of corticotropin-releasing hormone secretion; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of immunoglobulin production; cell surface receptor linked signal transduction; B cell differentiation; regulation of inflammatory response; positive regulation of cell proliferation; positive regulation of B cell proliferation; negative regulation of neuron apoptosis; positive regulation of astrocyte differentiation
Research Articles on CLCF1
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Product Notes
The CLCF1 clcf1 (Catalog #AAA2011613) is a Recombinant Protein produced from E.coli and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Cardiotrophin Like Cytokine Factor 1 (CLCF1) reacts with Mus musculus (Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's Cardiotrophin Like Cytokine Factor 1 (CLCF1) can be used in a range of immunoassay formats including, but not limited to, Positive Control; Immunogen; SDS-PAGE; Western Blot (WB). (May be suitable for use in other assays to be determined by the end user.). Researchers should empirically determine the suitability of the CLCF1 clcf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cardiotrophin Like Cytokine Factor 1 (CLCF1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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