Human cholinergic receptor, nicotinic, alpha 5 ELISA Kit | CHRNA5 elisa kit
Human Neuronal acetylcholine receptor subunit alpha-5, CHRNA5 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]
Uniprot Description
nAChRA5: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 5/CHRNA5 sub-subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 15q24
Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; plasma membrane; cell junction
Molecular Function: acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; ligand-gated ion channel activity
Biological Process: synaptic transmission; transport; behavioral response to nicotine; signal transduction; cation transport
Disease: Smoking As A Quantitative Trait Locus 3
Research Articles on CHRNA5
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Product Notes
The Human CHRNA5 chrna5 (Catalog #AAA9320937) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9320937 ELISA Kit recognizes Human CHRNA5. It is sometimes possible for the material contained within the vial of "cholinergic receptor, nicotinic, alpha 5, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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