R-Spondin-2 Active Protein | RSPO2 active protein
Human R-Spondin-2
NCBI and Uniprot Product Information
NCBI Description
R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008]
Uniprot Description
Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors. Ref.7 Ref.8 Ref.9
Subunit structure: Interacts with WNT1. Binds heparin
By similarity. Interacts with LGR4, LGR5 and LGR6. Ref.7 Ref.8 Ref.9
Subcellular location: Secreted
By similarity.
Domain: The FU repeat is required for activation and stabilization of beta-catenin
By similarity.
Miscellaneous: Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis (Ref.6).
Sequence similarities: Belongs to the R-spondin family.Contains 1 FU (furin-like) repeat.Contains 1 TSP type-1 domain.
Research Articles on RSPO2
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Product Notes
The RSPO2 rspo2 (Catalog #AAA691525) is an Active Protein produced from CHO Cells and is intended for research purposes only. The product is available for immediate purchase. The Human R-Spondin-2 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: ASYVSNPICK GCLSCSKDNG CSRCQQKLFF FLRREGMRQY GECLHS CPSG YYGHRAPDMN RCARCRIENC DSCFSKDFCT KCKVGFYLHR G RCFDECPDG FAPLEETMEC VEGCEVGHWS EWGTCSRNNR TCGFKWG LET RTRQIVKKPV KDTILCPTIA ESRRCKMTMR HCPGGKRTPK AK EKRNKKKK RKLIERAQEQ HSVFLATDRA NQ. It is sometimes possible for the material contained within the vial of "R-Spondin-2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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