ICAM-1 active protein
Human ICAM-1
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. Ref.12 Ref.13 Ref.14 Ref.18
Subunit structure: Homodimer
Probable. Interacts with human herpesvirus 8 MIR2 protein
Probable. Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus. Ref.14 Ref.15 Ref.18 Ref.29 Ref.30
Subcellular location: Membrane; Single-pass type I membrane protein.
Post-translational modification: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
Polymorphism: Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria [
MIM:611162].
Sequence similarities: Belongs to the immunoglobulin superfamily. ICAM family.Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Research Articles on ICAM-1
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Product Notes
The ICAM-1 icam1 (Catalog #AAA691840) is an Active Protein produced from CHO Cells and is intended for research purposes only. The product is available for immediate purchase. The Human ICAM-1 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: QTSVSPSKVI LPRGGSVLVT CSTSCDQPKL LGIETPLPKK ELLLPG NNRK VYELSNVQED SQPMCYSNCP DGQSTAKTFL TVYWTPERVE L APLPSWQPV GKNLTLRCQV EGGAPRANLT VVLLRGEKEL KREPAVG EPA EVTTTVLVRR DHHGANFSCR TELDLRPQGL ELFENTSAPY QL QTFVLPAT PPQLVSPRVL EVDTQGTVVC SLDGLFPVSE AQVHLALG DQ RLNPTVTYGN DSFSAKASVS VTAEDEGTQR LTCAVILGNQ SQE TLQTVTI YSFPAPNVIL TKPEVSEGTE VTVKCEAHPR AKVTLNGVP A QPLGPRAQLL LKATPEDNGR SFSCSATLEV AGQLIHKNQT RELR VLYGPR LDERDCPGNW TWPENSQQTP MCQAWGNPLP ELKCLKDGTF PLPIGESVTV TRDLEGTYLC RARSTQGEVT RKVTVNVLSP RYE. It is sometimes possible for the material contained within the vial of "ICAM-1, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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