CD22, soluble Active Protein | CD22 active protein
Human CD22, soluble
NCBI and Uniprot Product Information
Uniprot Description
Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Subunit structure: Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation
By similarity. May form a complex with INPP5D/SHIP, GRB2 and SHC1. Ref.8 Ref.9 Ref.10
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Tissue specificity: B-lymphocytes.
Domain: Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Post-translational modification: Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.Phosphorylated on tyrosine residues by LYN
By similarity.
Sequence similarities: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.Contains 6 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Sequence caution: The sequence CAA36988.1 differs from that shown. Reason: Frameshift at position 806.
Research Articles on CD22
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Product Notes
The CD22 cd22 (Catalog #AAA691835) is an Active Protein produced from CHO Cells and is intended for research purposes only. The product is available for immediate purchase. The Human CD22, soluble reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SKWVFEHPET LYAWEGACVW IPCTYRALDG DLESFILFHN PEYNKN TSKF DGTRLYESTK DGKVPSEQKR VQFLGDKNKN CTLSIHPVHL N DSGQLGLRM ESKTEKWMER IHLNVSERPF PPHIQLPPEI QESQEVT LTC LLNFSCYGYP IQLQWLLEGV PMRQAAVTST SLTIKSVFTR SE LKFSPQWS HHGKIVTCQL QDADGKFLSN DTVQLNVKHT PKLEIKVT PS DAIVREGDSV TMTCEVSSSN PEYTTVSWLK DGTSLKKQNT FTL NLREVTK DQSGKYCCQV SNDVGPGRSE EVFLQVQYAP EPSTVQILH S PAVEGSQVEF LCMSLANPLP TNYTWYHNGK EMQGRTEEKV HIPK ILPWHA GTYSCVAENI LGTGQRGPGA ELDVQYPPKK VTTVIQNPMP IREGDTVTLS CNYNSSNPSV TRYEWKPHGA WEEPSLGVLK IQNVG WDNTT IACARCNSWC SWASPVALNV QYAPRDVRVR KIKPLSEIHS GNSVSLQCDF SSSHPKEVQF FWEKNGRLLG KESQLNFDSI SPEDAG SYSC WVNNSIGQTA SKAWTLEVLY APRRLRVSMS PGDQVMEGKS A TLTCESDAN PPVSHYTWFD WNNQSLPHHS QKLRLEPVKV QHSGAYW CQG TNSVGKGRSP LSTLTVYYSP ETIGRR. It is sometimes possible for the material contained within the vial of "CD22, soluble, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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