Chicken Collagen and calcium-binding EGF domain-containing protein 1 (CCBE1) ELISA Kit | CCBE1 elisa kit
Chicken Collagen and calcium-binding EGF domain-containing protein 1 (CCBE1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. [provided by RefSeq, Mar 2010]
Uniprot Description
CCBE1: Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Defects in CCBE1 are the cause of Hennekam lymphangiectasia-lymphedema syndrome (HLLS). HLLS is a generalized lymph-vessels dysplasia characterized by intestinal lymphangiectasia with severe lymphedema of the limbs, genitalia and face. In addition, affected individuals have unusual facies and severe mental retardation. Belongs to the CCBE1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 18q21.32
Cellular Component: extracellular space; proteinaceous extracellular matrix; collagen
Molecular Function: collagen binding; protease binding; calcium ion binding
Biological Process: positive regulation of angiogenesis; venous blood vessel morphogenesis; lymphangiogenesis; sprouting angiogenesis
Disease: Hennekam Lymphangiectasia-lymphedema Syndrome 1
Research Articles on CCBE1
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Product Notes
The Chicken CCBE1 ccbe1 (Catalog #AAA7224747) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7224747 ELISA Kit recognizes Chicken CCBE1. It is sometimes possible for the material contained within the vial of "Collagen and calcium-binding EGF domain-containing protein 1 (CCBE1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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