Histone H3-like centromeric protein A (CENPA) Recombinant Protein | CENPA recombinant protein
Recombinant Chicken Histone H3-like centromeric protein A (CENPA)
Gene Names
CENPA; CENP-A; ggCENP-A
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Histone H3-like centromeric protein A (CENPA); Recombinant Chicken Histone H3-like centromeric protein A (CENPA); CENPA recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-131, Full length protein
Sequence
MPRPKPRSPRRRGRPPPAAPPPPPARPRARRYRPGQRALREIRRYQSSTALLLRRQPFARVVREICLLFTRGVDYRWQAMALLALQEAAEAFLVHLLEDAYLCSLHARRVTLYPKDLQLARRLRGLQGEGF
Sequence Length
131
Species
Chicken
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for CENPA recombinant protein
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
15,243 Da
NCBI Official Full Name
histone H3-like centromeric protein A
NCBI Official Synonym Full Names
centromere protein A
NCBI Official Symbol
CENPA
NCBI Official Synonym Symbols
CENP-A; ggCENP-A
NCBI Protein Information
histone H3-like centromeric protein A
UniProt Protein Name
Histone H3-like centromeric protein A
Protein Family
UniProt Gene Name
CENPA
UniProt Synonym Gene Names
CENP-A; GgCENP-A
Uniprot Description
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:14563550). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:15870271).
Research Articles on CENPA
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Product Notes
The CENPA cenpa (Catalog #AAA1409011) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-131, Full length protein. The amino acid sequence is listed below: MPRPKPRSPR RRGRPPPAAP PPPPARPRAR RYRPGQRALR EIRRYQSSTA LLLRRQPFAR VVREICLLFT RGVDYRWQAM ALLALQEAAE AFLVHLLEDA YLCSLHARRV TLYPKDLQLA RRLRGLQGEG F. It is sometimes possible for the material contained within the vial of "Histone H3-like centromeric protein A (CENPA), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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