ZHX1 cdna clone
ZHX1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011]
Uniprot Description
ZHX1: Acts as a transcriptional repressor. Increases DNMT3B- mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co- repressor proteins. Belongs to the ZHX family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 8q24.13
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; protein heterodimerization activity; transcription corepressor activity; transcription factor activity
Biological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Research Articles on ZHX1
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Product Notes
The ZHX1 zhx1 (Catalog #AAA1267168) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcaagca ggcgaaaatc aacaacacct tgcatggtcc ttgccagtga acaagatcca gaccttgagt tgatatcaga tttggatgaa ggtcctcctg tgcttacacc tgtagaaaac accagagcag agagtatctc aagtgatgaa gaggttcatg aatctgtgga ttcagacaat cagcaaaata aaaaagttga aggtggatat gaatgtaaat attgtacttt tcaaactcca gatctaaata tgtttacttt tcatgtggat tcggaacatc ccaatgtagt gctaaattca tcctatgttt gtgtcgaatg caattttctt accaaaaggt atgatgcact ttctgagcat aatctgaaat atcacccagg agaagagaat tttaagttga ctatggtgaa acgtaataac cagacaatct ttgaacaaac aataaatgat ctgacttttg atggtagttt tgttaaagag gagaatgcag agcaagcaga atctacagaa gtttcttctt cgggaatatc tatcagtaaa actcctatca tgaaaatgat gaaaaataaa gtggaaaata aacggattgc agttcatcat aactcagttg aggacgttcc tgaagagaaa gagaatgaaa tcaaaccaga ccgtgaagaa attgtagaaa atccaagttc ttcagcttct gaatctaata caagtacttc cattgtaaac agaatacatc caagtactgc cagcacggta gtgacaccag cagcagttct tcctggattg gcacagatga taactgctgt atctgctcag cagaattcta atttgattcc caaagtctta atccctgtta atagcattcc cacctacaat gctgcattgg ataacaatcc ccttttactt aacacctaca acaagttccc ttacccaaca atgtcagaaa ttacagttct ttctgctcaa gcaaaatata cagaggaaca gatcaagata tggttttcag cccaacgttt aaaacatggt gttagttgga ctcccgagga agtagaggag gcaagaagga aacaattcaa tggaacagtg catactgtac ctcagaccat aactgttatt cctacacaca tttccacagg gagtaatggt ttaccatcta ttttacagac atgccaaata gttggtcagc ctggtctggt ccttactcaa gtggctggaa caaacacctt gccagttaca gcacctatag ccttgacagt ggcaggcgtt ccaagtcaaa ataatataca gaaaagtcag gtacctgctg ctcagcctac tgcagaaaca aagccagcaa cagcagcagt tccaacttct caaagtgtca aacatgaaac tgcattggta aaccctgatt catttggcat tcgggcaaaa aagacaaaag agcaactggc agaattaaaa gttagctacc ttaaaaatca gtttccccat gattcagaaa ttatcagact tatgaaaata acaggcctga cgaaaggaga gattaaaaaa tggtttagtg acacaaggta caaccagaga aattcaaaga gtaatcagtg cttacatctc aacaatgatt cctctaccac cattattata gactccagtg atgaaaccac ggaatcccca actgttggta ctgcacagcc taagcaatcc tggaatcctt ttcctgactt tactccccaa aagtttaaag agaaaactgc agagcagctt cgtgtccttc aggcaagttt tctcaacagc tctgtactta cagatgaaga attaaatagg ttaagggcac aaaccaaact taccagaaga gaaatcgatg cttggtttac agagaagaag aaatcaaaag ctttaaagga agagaaaatg gaaatagatg aaagtaatgc aggtagttcc aaagaagaag ctggagaaac ttctcctgca gatgaatctg gtgcacctaa gtcagggagt acaggcaaga tatgtaaaaa aacacctgag cagctgcaca tgcttaagag tgcatttgtc cggacacagt ggccatcacc agaagagtat gacaagttgg ccaaagaaag cgggcttgct agaacagaca tagttagttg gtttggggac acccgttatg cttggaagaa tggaaacttg aaatggtact actactatca gagcgccaat tcaagtagta tgaatggtct gtcttccctt aggaaaagag ggagagggag acccaaagga cggggaagag gaagaccgcg tgggcggcct agaggaagca aaagaattaa caactgggac aggggaccat cactcataaa atttaaaact ggaactgcaa tacttaagga ttattacctg aagcgcaagt ttcttaatga gcaagacctt gatgaacttg ttaacaaatc acatatgggc tatgagcagg tcagagagtg gtttgcagaa agacagagaa gatcagaatt aggtatagaa ttatttgagg aaaatgagga ggaagatgaa gttattgatg accaggaaga ggatgaagaa gaaacagatg atagtgacac ttgggaacct ccacgacatg tgaaacggaa gctgtctaaa tcagatgact ga. It is sometimes possible for the material contained within the vial of "ZHX1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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