ZCCHC12 cdna clone

ZCCHC12 cDNA Clone

Cat. Num. AAA1270371

• Gene Names: ZCCHC12; SIZN; SIZN1; PNMA7A
• Synonyms: ZCCHC12; ZCCHC12 cDNA Clone; ZCCHC12 cdna clone

• Sequence: atggctagcatcattgcacgtgtcggtaacagccggcggctgaatgcacccttgccgccttgggcccattccatgctgaggtccctggggagaagtctcggtcctataatggccagcatggcagacagaaacatgaagttgttctcggggagggtggtgccagcccaaggggaagaaacctttgaaaactggctgacccaagtcaatggcgtcctgccagattggaatatgtctgaggaggaaaagctcaagcgcttgatgaaaacccttaggggccctgcccgcgaggtcatgcgtgtgcttcaggcgaccaaccctaacctaagtgtggcagatttcttgcgagccatgaaattggtgtttggggagtctgaaagcagtgtgactgcccatggtaaattttttaacaccctacaagctcaaggggagaaagcctccctttatgtgatccgtttagaggtgcagctccagaacgctattcaggcaggcattatagctgagaaagatgcaaaccggactcgcttgcagcagctccttttaggcggtgagctgagtagggacctccgactcagacttaaggattttctcaggatgtatgcaaatgagcaggagcggcttcccaactttctggagttaatcagaatggtaagggaggaagaggattgggatgatgcttttattaaacggaagcgtccaaaaaggtctgagtcaatggtggagagggcagtcagccctgtggcatttcagggctccccaccgatagtgatcggcagtgctgactgcaatgtgatagagatagatgataccctcgacgactccgatgaggatgtgatcctggtggagtctcaggaccctccacttccatcctggggtgcccctcccctcagagacagggccagacctcaggatgaagtgctggtcattgattccccccacaattccagggctcagtttccttccaccagtggtggttctggctataagaataacggtcctggggagatgcgtagagccaggaagcgaaaacacacaatccgctgttcgtattgtggtgaggaaggccactcaaaagaaacctgtgacaacgagagtgacaaggcccaggtttttgagaatttgatcatcactctccaggagctgacccatactgagatggagaggtcaagagtggcccctggcgaatacaatgacttctctgagccactgtaa
• Sequence Length: 1209

• Vector: pENTR223.1 or pUC
• Clone Sequence Report: Provided with product shipment

NCBI and Uniprot Product Information

• NCBI GI #: 21411483
• NCBI GeneID: 170261
• Molecular Weight: 45,369 Da
• NCBI Official Full Name: Homo sapiens zinc finger, CCHC domain containing 12, mRNA
• NCBI Official Synonym Full Names: zinc finger CCHC-type containing 12
• NCBI Official Symbol: ZCCHC12
• NCBI Official Synonym Symbols: SIZN; SIZN1; PNMA7A
• NCBI Protein Information: zinc finger CCHC domain-containing protein 12
• UniProt Protein Name: Zinc finger CCHC domain-containing protein 12
• Protein Family: Zinc finger CCHC domain-containing protein
• UniProt Gene Name: ZCCHC12
• UniProt Synonym Gene Names: SIZN1
• UniProt Entry Name: ZCH12_HUMAN

NCBI Description

This gene encodes a downstream effector of bone morphogenetic protein (BMP) signalling. This protein contains a zinc finger domain and functions as a transcriptional coactivator. Variation in this gene may be associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Uniprot Description

ZCCHC12: Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression. Belongs to the ZCCHC12 family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: nuclear speck

Molecular Function: ligand-dependent nuclear receptor transcription coactivator activity; protein binding

Biological Process: BMP signaling pathway