VNN2 cdna clone
VNN2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Uniprot Description
VNN2: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil. Belongs to the CN hydrolase family. BTD/VNN subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, GPI anchor; EC 3.5.1.92
Chromosomal Location of Human Ortholog: 6q23-q24
Molecular Function: pantetheine hydrolase activity
Biological Process: biotin metabolic process; cell motility; central nervous system development; pantothenate metabolic process
Research Articles on VNN2
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Product Notes
The VNN2 vnn2 (Catalog #AAA1275095) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggtcactt cctcttttcc aatctctgtg gcagtttttg ccctaataac cctgcaggtt ggtactcagg acagttttat agctgcagtg tatgaacatg ctgtcatttt gccaaataaa acagaaacac cagtttctca ggaggatgcc ttgaatctca tgaacgagaa tatagacatt ctggagacag cgatcaagca ggcagctgag cagggtgctc gaatcattgt gactccagaa gatgcacttt atggatggaa atttaccagg gaaactgttt tcccttatct ggaggatatc ccagaccctc aggtgaactg gattccgtgt caagaccccc acagatttgg tcacacacca gtacaagcaa gactcagctg cctggccaag gacaactcta tctatgtctt ggcaaatttg ggggacaaaa agccatgtaa ttcccgtgac tccacgtgtc ctcctaatgg ctactttcaa tacaatacca atgtggtgta taatacagaa ggaaaactcg tggcacgtta ccataagtac cacctgtact ctgagcctca gtttaatgtc cctgaaaagc cggagttggt gactttcaac accgcatttg gaaggtttgg cattttcacg tgctttgata tattcttcta tgatcctggt gttaccctgg tgaaagattt ccatgtggac accatactgt ttcccacagc ttggatgaac gttttgcccc ttttgacagc tattgaattc cattcagctt gggcaatggg aatgggagtt aatcttcttg tggccaacac acatcatgtc agcctaaata tgacaggaag tggcatttat gcaccaaatg gtcccaaagt gtatcattat gacatgaaga cagagttggg aaaacttctc ctttcagagg tggattcaca tcccctatcc tcgcttgcct acccaacagc tgttaattgg aatgcctacg ccaccaccat caaaccattt ccagtacaga aaaacacttt caggggattt atttccaggg atgggttcaa cttcacagaa ctttttgaaa atgcaggaaa ccttacagtc tgtcaaaagg agctttgctg tcatttaagc tacagaatgt tacaaaaaga agagaatgaa gtatacgttc taggagcttt tacaggatta catggccgaa ggagaagaga gtactggcag gtctgcacaa tgctgaagtg caaaactact aatttgacaa cttgtggacg gccagtagaa actgcttcta caagatttga aatgttctcc ctcagtggca catttggaac agagtatgtt tttcctgaag tgctacttac cgaaattcat ctgtcacctg gaaaatttga ggtgctgaaa gatgggcgtt tggtaaacaa gaatggatca tctgggccta tactaacagt gtcactcttt gggaggtggt acacaaagga ctcactttac agctcatgtg ggaccagcaa ttcagcaata acttacctgc taatattcat attattaatg atcatagctt tgcaaaatat tgtaatgtta tag. It is sometimes possible for the material contained within the vial of "VNN2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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