Western Blot (WB)
(VNN2 polyclonal antibody. Western Blot analysis of VNN2 expression in HeLa.)
Mouse anti-Human VNN2 Polyclonal Antibody | anti-VNN2 antibody
VNN2 (Vascular Non-inflammatory Molecule 2, Vanin-2, Glycosylphosphatidyl Inositol-anchored Protein GPI-80, Protein FOAP-4)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(VNN2 polyclonal antibody. Western Blot analysis of VNN2 expression in HeLa.)
Western Blot (WB)
(VNN2 polyclonal antibody. Western Blot analysis of VNN2 expression in HeLa.)
Western Blot (WB)
(Western Blot analysis of VNN2 expression in transfected 293T cell line by VNN2 polyclonal antibody. Lane1:VNN2 transfected lysate (51.37kD). Lane2:Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of VNN2 expression in transfected 293T cell line by VNN2 polyclonal antibody. Lane1:VNN2 transfected lysate (51.37kD). Lane2:Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Uniprot Description
VNN2: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil. Belongs to the CN hydrolase family. BTD/VNN subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.5.1.92; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 6q23-q24
Cellular Component: plasma membrane
Molecular Function: pantetheine hydrolase activity
Biological Process: pantothenate metabolic process; cell motility
Research Articles on VNN2
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Product Notes
The VNN2 vnn2 (Catalog #AAA6008886) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The VNN2 (Vascular Non-inflammatory Molecule 2, Vanin-2, Glycosylphosphatidyl Inositol-anchored Protein GPI-80, Protein FOAP-4) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's VNN2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the VNN2 vnn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MNENIDILET AIKQAAEQGA RIIVTPEDAL YGWKFTRETV FPYLEDIPDP QVNWIPCQDP HRFGHTPVQA RLSCLAKDNS IYVLANLGDK KPCNSRDSTC PPNGYFQYNT NVVYNTEGKL VARYHKYHLY SEPQFNVPEK PELVTFNTAF GRFGIFTCFD IFFYDPGVTL VKDFHVDTIL FPTAWMNVLP LLTAIEFHSA WAMGMGVNLL VANTHHVSLN MTGSGIYAPN GPKVYHYDMK TELGKLLLSE VDSHPLSSLA YPTAVNWNAY ATTIKPFPVQ KNTFRGFISR DGFNFTELFE NAGNLTVCQK ELCCHLSYRM LQKEENEVYV LGAFTGLHGR RRREYWQVCT MLKCKTTNLT TCGRPVETAS TRFEMFSLSG TFGTEYVFPE VLLTEIHLSP GKFEVLKDGR LVNKNGSSGP ILTVSLFGRW YTKDSLYSSC GTSNSAITYL LIFILLMIIA LQNIVML. It is sometimes possible for the material contained within the vial of "VNN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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