VCP cdna clone
VCP cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008]
Uniprot Description
VCP: valosin-containing protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope and of the transitional endoplasmic reticulum (tER). Regulates NFKappaB pathway, which is important for metastasis of osteosarcoma. Tyrosine phosphorylation regulates its cell cycle-dependent nuclear localization.
Protein type: Endoplasmic reticulum; DNA repair, damage; Chaperone; EC 3.6.4.6; Hydrolase
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bound organelle; lipid particle; nucleoplasm; nucleus; perinuclear region of cytoplasm; proteasome complex
Molecular Function: ATPase activity; identical protein binding; polyubiquitin binding; protein binding; protein domain specific binding; protein phosphatase binding; ubiquitin protein ligase binding
Biological Process: autophagy; bypass DNA synthesis; caspase activation; double-strand break repair; ER-associated protein catabolic process; establishment of protein localization; NADH metabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; positive regulation of protein complex assembly; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid N-linked glycosylation via asparagine; protein ubiquitination; regulation of apoptosis; response to DNA damage stimulus; retrograde protein transport, ER to cytosol; unfolded protein response; viral genome replication
Disease: Amyotrophic Lateral Sclerosis 14, With Or Without Frontotemporal Dementia; Charcot-marie-tooth Disease, Axonal, Type 2y; Inclusion Body Myopathy With Early-onset Paget Disease With Or Without Frontotemporal Dementia 1
Research Articles on VCP
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Product Notes
The VCP vcp (Catalog #AAA1268645) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCTTCTG GAGCCGATTC AAAAGGTGAT GACCTATCAA CAGCCATTCT CAAACAGAAG AACCGTCCCA ATCGGTTAAT TGTTGATGAA GCCATCAATG AGGACAACAG TGTGGTGTCC TTGTCCCAGC CCAAGATGGA TGAATTGCAG TTGTTCCGAG GTGACACAGT GTTGCTGAAA GGAAAGAAGA GACGAGAAGC TGTTTGCATC GTCCTTTCTG ATGATACTTG TTCTGATGAG AAGATTCGGA TGAATAGAGT TGTTCGGAAT AACCTTCGTG TACGCCTAGG GGATGTCATC AGCATCCAGC CATGCCCTGA TGTGAAGTAC GGCAAACGTA TCCATGTGCT GCCCATTGAT GACACAGTGG AAGGCATTAC TGGTAATCTC TTCGAGGTAT ACCTTAAGCC GTACTTCCTG GAAGCGTATC GACCCATCCG GAAAGGAGAC ATTTTTCTTG TCCGTGGTGG GATGCGTGCT GTGGAGTTCA AAGTGGTGGA AACACATCCT AGCCCTTATT GCATTGTTGC TCCAGACACA GTGATCCACT GCGAAGGGGA GCCTATCAAA CGAGAGGATG AGGAAGAGTC CTTGAATGAA GTAGGGTATG ATGACATTGG TGGCTGCAGG AAGCAGCTAG CTCAGATAAA GGAGATGGTG GAACTGCCCC TGAGACATCC TGCCCTCTTT AAGGCAATTG GTGTGAAGCC TCCTAGAGGA ATCCTGCTTT ACGGACCTCC TGGAACAGGA AAGACCCTGA TTGCTCGAGC TGTAGCAAAT GAGACTGGAG CCTTCTTCTT CTTGATCAAT GGTCCTGAGA TCATGAGCAA ATTGGCTGGT GAGTCTGAGA GCAACCTTCG TAAAGCCTTT GAGGAGGCTG AGAAGAATGC TCCTGCCATC ATCTTCATTG ATGAGCTAGA TGCCATCGCT CCCAAAAGAG AGAAAACTCA TGGCGAGGTG GAGCGGCGCA TTGTATCACA GTTGTTGACC CTCATGGATG GCCTAAAGCA GAGGGCACAT GTGATTGTTA TGGCAGCAAC CAACAGACCC AACAGCATTG ACCCAGCTCT ACGGCGATTT GGTCGCTTTG ACAGGGAGGT AGATATTGGA ATTCCTGATG CTACAGGACG CTTAGAGATT CTTCAGATCC ATACCAAGAA CATGAAGCTG GCAGATGATG TGGACCTGGA ACAGGTAGCC AATGAGACTC ACGGGCATGT GGGTGCTGAC TTAGCAGCCC TGTGCTCAGA GGCTGCTCTG CAAGCCATCC GCAAGAAGAT GGATCTCATT GACCTAGAGG ATGAGACCAT TGATGCCGAG GTCATGAACT CTCTAGCAGT TACTATGGAT GACTTCCGGT GGGCCTTGAG CCAGAGTAAC CCATCAGCAC TGCGGGAAAC CGTGGTAGAG GTGCCACAGG TAACCTGGGA AGACATCGGG GGCCTAGAGG ATGTCAAACG TGAGCTACAG GAGCTGGTCC AGTATCCTGT GGAGCACCCA GACAAATTCC TGAAGTTTGG CATGACACCT TCCAAGGGAG TTCTGTTCTA TGGACCTCCT GGCTGTGGGA AAACTTTGTT GGCCAAAGCC ATTGCTAATG AATGCCAGGC CAACTTCATC TCCATCAAGG GTCCTGAGCT GCTCACCATG TGGTTTGGGG AGTCTGAGGC CAATGTCAGA GAAATCTTTG ACAAGGCCCG CCAAGCTGCC CCCTGTGTGC TATTCTTTGA TGAGCTGGAT TCGATTGCCA AGGCTCGTGG AGGTAACATT GGAGATGGTG GTGGGGCTGC TGACCGAGTC ATCAACCAGA TCCTGACAGA AATGGATGGC ATGTCCACAA AAAAAAATGT GTTCATCATT GGCGCTACCA ACCGGCCTGA CATCATTGAT CCTGCCATCC TCAGACCTGG CCGTCTTGAT CAGCTCATCT ACATCCCACT TCCTGATGAG AAGTCCCGTG TTGCCATCCT CAAGGCTAAC CTGCGCAAGT CCCCAGTTGC CAAGGATGTG GACTTGGAGT TCCTGGCTAA AATGACTAAT GGCTTCTCTG GAGCTGACCT GACAGAGATT TGCCAGCGTG CTTGCAAGCT GGCCATCCGT GAATCCATCG AGAGTGAGAT TAGGCGAGAA CGAGAGAGGC AGACAAACCC ATCAGCCATG GAGGTAGAAG AGGATGATCC AGTGCCTGAG ATCCGTCGAG ATCACTTTGA AGAAGCCATG CGCTTTGCGC GCCGTTCTGT CAGTGACAAT GACATTCGGA AGTATGAGAT GTTTGCCCAG ACCCTTCAGC AGAGTCGGGG CTTTGGCAGC TTCAGATTCC CTTCAGGGAA CCAGGGTGGA GCTGGCCCCA GTCAGGGCAG TGGAGGCGGC ACAGGTGGCA GTGTATACAC AGAAGACAAT GATGATGACC TGTATGGCTA A. It is sometimes possible for the material contained within the vial of "VCP, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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