TNFAIP1 cdna clone
TNFAIP1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]
Uniprot Description
TNFAIP1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. Belongs to the BACURD family.
Protein type: DNA replication; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 17q22-q23
Cellular Component: cytoplasm; endosome; nucleolus
Molecular Function: GTP-Rho binding; protein binding; ubiquitin-protein ligase activity
Biological Process: apoptosis; cell migration; DNA replication; embryonic development; immune response; negative regulation of Rho protein signal transduction; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; stress fiber formation
Research Articles on TNFAIP1
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Product Notes
The TNFAIP1 tnfaip1 (Catalog #AAA1273578) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtcggggg acacctgcct gtgcccagcc tcaggggcca agcccaagct cagtggcttc aagggaggag ggttgggcaa caagtatgtc cagctcaacg tgggcggctc tctgtactac accactgtgc gggccctgac ccgccacgac accatgctca aggccatgtt cagtgggcgc atggaggtgc tgaccgacaa agaaggctgg atcctcatag accgttgtgg aaagcacttt ggcaccattt tgaattacct ccgagatgac accatcaccc tccctcagaa ccggcaagaa atcaaggaat tgatggctga agcaaagtat tacctcatcc aggggctggt gaatatgtgc cagagtgccc tgcaggacaa gaaggactcc taccagcctg tgtgcaacat ccccatcatc acatccctaa aggaggagga gcggctcatc gaatcctcca ccaagcccgt ggtgaagctg ctgtacaaca gaagcaacaa caagtattcc tacaccagca actctgacga ccacctgctg aaaaacatcg agctgtttga caagctctcc ctgcgcttca acggccgcgt gctcttcatc aaggatgtca ttggtgacga gatctgctgc tggtcctttt atggccaggg ccgtaagctg gcagaggtgt gctgtacctc catcgtgtat gccacggaga agaagcagac caaggtggaa ttcccagagg cccgaatcta tgaggagaca ctcaacgtcc tactctatga gactccccgc gtccccgaca actccttgtt ggaggccaca agccgtagcc gcagccaggc ttcccccagt gaagatgagg agacctttga actgcgggac cgtgtccgcc gcatccacgt caagcgctac agcacttacg atgaccggca gctcggccac cagtctaccc atcgcgactg a. It is sometimes possible for the material contained within the vial of "TNFAIP1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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