TLR6 cdna clone
TLR6 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]
Uniprot Description
TLR6: Participates in the innate immune response to Gram- positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. Belongs to the Toll-like receptor family.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 4p14
Cellular Component: Golgi apparatus; integral to plasma membrane; lipid raft; plasma membrane
Molecular Function: protein binding; receptor activity; transmembrane receptor activity
Biological Process: defense response to bacterium; detection of diacylated bacterial lipoprotein; immune response; interleukin-1 beta secretion; MyD88-dependent toll-like receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK activity; signal transduction; T-helper 1 type immune response; toll-like receptor signaling pathway
Research Articles on TLR6
Similar Products
Product Notes
The TLR6 tlr6 (Catalog #AAA1267949) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGACCAAAG ACAAAGAACC TATTGTTAAA AGCTTCCATT TTGTTTGCCT TATGATCATA ATAGTTGGAA CCAGAATCCA GTTCTCCGAC GGAAATGAAT TTGCAGTAGA CAAGTCAAAA AGAGGTCTTA TTCATGTTCC AAAAGACCTA CCGCTGAAAA CCAAAGTCTT AGATATGTCT CAGAACTACA TCGCTGAGCT TCAGGTCTCT GACATGAGCT TTCTATCAGA GTTGACAGTT TTGAGACTTT CCCATAACAG AATCCAGCTA CTTGATTTAA GTGTTTTCAA GTTCAACCAG GATTTAGAAT ATTTGGATTT ATCTCATAAT CAGTTGCAAA AGATATCCTG CCATCCTATT GTGAGTTTCA GGCATTTAGA TCTCTCATTC AATGATTTCA AGGCCCTGCC CATCTGTAAG GAATTTGGCA ACTTATCACA ACTGAATTTC TTGGGATTGA GTGCTATGAA GCTGCAAAAA TTAGATTTGC TGCCAATTGC TCACTTGCAT CTAAGTTATA TCCTTCTGGA TTTAAGAAAT TATTATATAA AAGAAAATGA GACAGAAAGT CTACAAATTC TGAATGCAAA AACCCTTCAC CTTGTTTTTC ACCCAACTAG TTTATTCGCT ATCCAAGTGA ACATATCAGT TAATACTTTA GGGTGCTTAC AACTGACTAA TATTAAATTG AATGATGACA ACTGTCAAGT TTTCATTAAA TTTTTATCAG AACTCACCAG AGGTCCAACC TTACTGAATT TTACCCTCAA CCACATAGAA ACGACTTGGA AATGCCTGGT CAGAGTCTTT CAATTTCTTT GGCCCAAACC TGTGGAATAT CTCAATATTT ACAATTTAAC AATAATTGAA AGCATTCGTG AAGAAGATTT TACTTATTCT AAAACGACAT TGAAAGCATT GACAATAGAA CATATCACGA ACCAAGTTTT TCTGTTTTCA CAGACAGCTT TGTACACCGT GTTTTCTGAG ATGAACATTA TGATGTTAAC CATTTCAGAT ACACCTTTTA TACACATGCT GTGTCCTCAT GCACCAAGCA CATTCAAGTT TTTGAACTTT ACGCAGAACG TTTTCACAGA TAGTATTTTT GAAAAATGTT CCACGTTAGT TAAATTGGAG ACACTTATCT TTGTTTTGTC TCCCAACTTT GTCCAGAGTG AGTGGTGCCA TTACGAACTC TATTTTGCCC ATCACAATCT CTTTCATGAA GGATCTAATA ACTTAATCCT CATCTTACTG GAACCCATTC CACAGAACAG CATTCCCAAC AAGTACCACA AGCTGAAGGC TCTCATGACG CAGCGGACTT ATTTGCAGTG GCCCAAGGAG AAAAGCAAAC GTGGGCTCTT TTGGGCTAAC ATTAGAGCCG CTTTTAATAT GAAATTAACA CTAGTCACTG AAAACAATGA TGTGAAATCT TAA. It is sometimes possible for the material contained within the vial of "TLR6, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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