TLR1 cdna clone
TLR1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
TLR1: Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Binds MYD88 (via TIR domain). Interacts with CNPY3. Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2. Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. Belongs to the Toll-like receptor family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p14
Cellular Component: Golgi apparatus; integral to plasma membrane; lipid raft; plasma membrane
Molecular Function: protein binding; protein heterodimerization activity; receptor activity; transmembrane receptor activity
Biological Process: defense response to bacterium; detection of triacylated bacterial lipoprotein; immune response; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-6 biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; signal transduction; toll-like receptor signaling pathway
Disease: Leprosy, Susceptibility To, 5
Research Articles on TLR1
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Product Notes
The TLR1 tlr1 (Catalog #AAA1277542) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGACTAGCA TCTTCCATTT TGCCATTATC TTCATGTTAA TACTTCAGAT CAGAATACAA TTATCTGAAG AAAGTGAATT TTTAGTTGAT AGGTCAAAAA ACGGTCTCAT CCACGTTCCT AAAGACCTAT CCCAGAAAAC AACAATCTTA AATATATCGC AAAATTATAT ATCTGAGCTT TGGACTTCTG ACATCTTATC ACTGTCAAAA CTGAGGATTT TGATAATTTC TCATAATAGA ATCCAGTATC TTGATATCAG TGTTTTCAAA TTCAACCAGG AATTGGAATA CTTGGATTTG TCCCACAACA AGTTGGTGAA GATTTCTTGC CACCCTACTG TGAACCTCAA GCACTTGGAC CTGTCATTTA ATGCATTTGA TGCCCTGCCT ATATGCAAAG AGTTTGGCAA TATGTCTCAA CTAAAATTTC TGGGGTTGAG CACCACACAC TTAGAAAAAT CTAGTGTGCT GCCAATTGCT CATTTGAATA TCAGCAAGGT CTTGCTGGTC TTAGGAGAGA CTTATGGGGA AAAAGAAGAC CCTGAGGGCC TTCAAGACTT TAACACTGAG AGTCTGCACA TTGTGTTCCC CACAAACAAA GAATTCCATT TTATTTTGGA TGTGTCAGTC AAGACTGTAG CAAATCTGGA ACTATCTAAT ATCAAATGTG TGCTAGAAGA TAACAAATGT TCTTACTTCC TAAGTATTCT GGCGAAACTT CAAACAAATC CAAAGTTATC AAATCTTACC TTAAACAACA TTGAAACAAC TTGGAATTCT TTCATTAGGA TCCTCCAGCT GGTTTGGCAT ACAACTGTAT GGTATTTCTC AATTTCAAAC GTGAAGCTAC AGGGTCAGCT GGACTTCAGA GATTTTGATT ATTCTGGCAC TTCCTTGAAG GCCTTGTCTA TACACCAAGT TGTCAGCGAT GTGTTCGGTT TTCCGCAAAG TTATATCTAT GAAATCTTTT CGAATATGAA CATCAAAAAT TTCACAGTGT CTGGTACACG CATGGTCCAC ATGCTTTGCC CATCCAAAAT TAGCCCGTTC CTGCATTTGG ATTTTTCCAA TAATCTCTTA ACAGACACGG TTTTTGAAAA TTGTGGGCAC CTTACTGAGT TGGAGACACT TATTTTACAA ATGAATCAAT TAAAAGAACT TTCAAAAATA GCTGAAATGA CTACACAGAT GAAGTCTCTG CAACAATTGG ATATTAGCCA GAATTCTGTA AGCTATGATG AAAAGAAAGG AGACTGTTCT TGGACTAAAA GTTTATTAAG TTTAAATATG TCTTCAAATA TACTTACTGA CACTATTTTC AGATGTTTAC CTCCCAGGAT CAAGGTACTT GATCTTCACA GCAATAAAAT AAAGAGCATT CCTAAACAAG TCGTAAAACT GGAAGCTTTG CAAGAACTCA ATGTTGCTTT CAATTCTTTA ACTGACCTTC CTGGATGTGG CAGCTTTAGC AGCCTTTCTG TATTGATCAT TGATCACAAT TCAGTTTCCC ACCCATCGGC TGATTTCTTC CAGAGCTGCC AGAAGATGAG GTCAATAAAA GCAGGGGACA ATCCATTCCA ATGTACCTGT GAGCTAGGAG AATTTGTCAA AAATATAGAC CAAGTATCAA GTGAAGTGTT AGAGGGCTGG CCTGATTCTT ATAAGTGTGA CTACCCGGAA AGTTATAGAG GAACCCTACT AAAGGACTTT CACATGTCTG AATTATCCTG CAACATAACT CTGCTGATCG TCACCATCGT TGCCACCATG CTGGTGTTGG CTGTGACTGT GACCTCCCTC TGCAGCTACT TGGATCTGCC CTGGTATCTC AGGATGGTGT GCCAGTGGAC CCAGACCCGG CGCAGGGCCA GGAACATACC CTTAGAAGAA CTCCAAAGAA ATCTCCAGTT TCATGCATTT ATTTCATATA GTGGGCACGA TTCTTTCTGG GTGAAGAATG AATTATTGCC AAACCTAGAG AAAGAAGGTA TGCAGATTTG CCTTCATGAG AGAAACTTTG TTCCTGGCAA GAGCATTGTG GAAAATATCA TCACCTGCAT TGAGAAGAGT TACAAGTCCA TCTTTGTTTT GTCTCCCAAC TTTGTCCAGA GTGAATGGTG CCATTATGAA CTCTACTTTG CCCATCACAA TCTCTTTCAT GAAGGATCTA ATAGCTTAAT CCTGATCTTG CTGGAACCCA TTCCGCAGTA CTCCATTCCT AGCAGTTATC ACAAGCTCAA AAGTCTCATG GCCAGGAGGA CTTATTTGGA ATGGCCCAAG GAAAAGAGCA AACGTGGCCT TTTTTGGGCT AACTTAAGGG CAGCCATTAA TATTAAGCTG ACAGAGCAAG CAAAGAAATA G. It is sometimes possible for the material contained within the vial of "TLR1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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