SPHK1 cdna clone
SPHK1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Description
SPHK1: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. Interacts with ACY1. Binds to calmodulin. Interacts with SPHKAP. Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.1.91; Lipid Metabolism - sphingolipid; Kinase, lipid
Chromosomal Location of Human Ortholog: 17q25.2
Cellular Component: synaptic vesicle; axon; cytoplasm; plasma membrane; cytosol; nucleus
Molecular Function: D-erythro-sphingosine kinase activity; calmodulin binding; protein binding; DNA binding; protein phosphatase 2A binding; sphinganine kinase activity; magnesium ion binding; diacylglycerol kinase activity; ATP binding; NAD+ kinase activity
Biological Process: protein folding; positive regulation of NF-kappaB import into nucleus; female pregnancy; signal transduction; positive regulation of mitotic cell cycle; positive regulation of neurotransmitter secretion; activation of NF-kappaB transcription factor; 'de novo' posttranslational protein folding; response to magnesium ion; positive regulation of fibroblast proliferation; regulation of interleukin-1 beta production; protein kinase C activation; positive regulation of smooth muscle contraction; inflammatory response; blood vessel development; sphingolipid metabolic process; sphingolipid biosynthetic process; cyclooxygenase pathway; calcium-mediated signaling; sphingosine metabolic process; lipid phosphorylation; cellular response to starvation; positive regulation of cell growth; response to ATP; positive regulation of angiogenesis; cellular protein metabolic process; positive regulation of protein ubiquitination; brain development; positive regulation of protein amino acid phosphorylation; response to progesterone stimulus; vascular endothelial growth factor receptor signaling pathway; response to amine stimulus; positive regulation of cell migration; sphingoid catabolic process; negative regulation of apoptosis
Research Articles on SPHK1
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Product Notes
The SPHK1 sphk1 (Catalog #AAA1267255) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggatccag tggtcggttg cggacgtggc ctctttggtt ttgttttctc agcgggcggc ccccggggcg tgctcccgcg gccctgccgc gtgctggtgc tgctgaaccc gcgcggcggc aagggcaagg ccttgcagct cttccggagt cacgtgcagc cccttttggc tgaggctgaa atctccttca cgctgatgct cactgagcgg cggaaccacg cgcgggagct ggtgcggtcg gaggagctgg gccgctggga cgctctggtg gtcatgtctg gagacgggct gatgcacgag gtggtgaacg ggctcatgga gcggcctgac tgggagaccg ccatccagaa gcccctgtgt agcctcccag caggctctgg caacgcgctg gcagcttcct tgaaccatta tgctggctat gagcaggtca ccaatgaaga cctcctgacc aactgcacgc tattgctgtg ccgccggctg ctgtcaccca tgaacctgct gtctctgcac acggcttcgg ggctgcgcct cttctctgtg ctcagcctgg cctggggctt cattgctgat gtggacctag agagtgagaa gtatcggcgt ctgggggaga tgcgcttcac tctgggcacc ttcctgcgtc tggcagccct gcgcacctac cgcggccgac tggcctacct ccctgtagga agagtgggtt ccaagacacc tgcctccccc gttgtggtcc agcagggccc ggtagatgca caccttgtgc cactggagga gccagtgccc tctcactgga cagtggtgcc cgacgaggac tttgtgctag tcctggcact gctgcactcg cacctgggca gtgagatgtt tgctgcaccc atgggccgct gtgcagctgg cgtcatgcat ctgttctacg tgcgggcggg agtgtctcgt gccatgctgc tgcgcctctt cctggccatg gagaagggca ggcatatgga gtatgaatgc ccctacttgg tatatgtgcc cgtggtcgcc ttccgcttgg agcccaagga tgggaaaggt gtgtttgcag tggatgggga attgatggtt agcgaggccg tgcagggcca ggtgcaccca aactacttct ggatggtcag cggttgcgtg gagcccccgc ccagctggaa gccccagcag atgccaccgc cagaagagcc cttatga. It is sometimes possible for the material contained within the vial of "SPHK1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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