Western Blot (WB)
(ERVWE1 Antibody (C-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the ERVWE1 antibody detected the ERVWE1 protein (arrow).)
Rabbit anti-Human ERVWE1 Polyclonal Antibody | anti-ERVW-1 antibody
ERVWE1 Antibody (C-term)
Western Blot (WB)
(ERVWE1 Antibody (C-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the ERVWE1 antibody detected the ERVWE1 protein (arrow).)
Western Blot (WB)
(ERVWE1 Antibody (C-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the ERVWE1 antibody detected the ERVWE1 protein (arrow).)
are expressed in normal placental tissue at high levels, suggesting
that HERVs are functionally important in reproduction. This gene is
part of an HERV provirus on chromosome 7 that has inactivating
mutations in the gag and pol genes. This gene is the envelope
glycoprotein gene which appears to have been selectively preserved.
The gene's protein product is expressed in the placental
syncytiotrophoblast and is involved in fusion of the
cytotrophoblast cells to form the syncytial layer of the placenta.
The protein has the characteristics of a typical retroviral
envelope protein, including a furin cleavage site that separates
the surface (SU) and transmembrane (TM) proteins which form a
heterodimer. Alternatively spliced transcript variants encoding the
same protein have been found for this gene.
Oppelt, P., et al. Gynecol. Endocrinol. 25(11):741-747(2009)
Gimenez, J., et al. DNA Res. 16(4):195-211(2009)
Larsen, J.M., et al. Cancer Lett. 280(1):44-49(2009)
Noorali, S., et al. Appl. Immunohistochem. Mol. Morphol. 17(4):319-328(2009)
NCBI and Uniprot Product Information
NCBI Description
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Description
ERVWE1: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis. Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.
Protein type: Membrane protein, integral; Cell surface
Chromosomal Location of Human Ortholog: 7q21.2
Cellular Component: integral to membrane; plasma membrane; viral envelope
Biological Process: anatomical structure morphogenesis; syncytium formation
Research Articles on ERVW-1
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Product Notes
The ERVW-1 ervw-1 (Catalog #AAA9212801) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 493-521. The ERVWE1 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ERVWE1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the ERVW-1 ervw-1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERVWE1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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