SMARCC1 cdna clone
SMARCC1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. [provided by RefSeq, Jul 2008]
Uniprot Description
SMARCC1: a core component of the BAF (SWI/SNF) complex. This family of complexes remodels chromatin structures, enabling transcription factors to gain access to DNA. They play important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling is due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain BAF53A and PHF10, are exchanged for homologous alternative BAF53B and BAF45B or BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand- bound VDR-mediated transrepression of the CYP27B1 gene. Component of 6 multiprotein chromatin-remodeling complexes: Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, Brg1(I), WINAC and Brg1(II). Each of the five complexes contains a catalytic subunit (either SMARCA4 or SMARCA2), and at least SMARCE1, BAF53A or BAF53B, SMARCC2 and SMARCB1. Other subunits specific to each of the complexes may also be present. Component of the BAF (hSWI/SNF) complex, which includes at least actin (ACTB), ARID1A, ARID1B, SMARCA2, SMARCA4, BAF53A, BAF53B, SMARCE1 SMARCC1, SMARCC2, SMARCB1, and one or more of SMARCD1, SMARCD2, or SMARCD3. In muscle cells, the BAF complex also contains DPF3. May also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 and SMARCA4. The minimal complex composed of SMARCC1 and SMARCA4 seems to be able to associate with cyclin such as CCNE1 or transcription factors such as KLF1 or GATA1. Expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney and pancreas. Belongs to the SMARCC family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: nuclear chromatin; nucleoplasm; protein complex; SWI/SNF complex
Molecular Function: nucleosomal DNA binding; protein binding; protein N-terminus binding
Biological Process: ATP-dependent chromatin remodeling; chromatin remodeling; nucleosome disassembly; positive regulation of transcription, DNA-dependent
Research Articles on SMARCC1
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Product Notes
The SMARCC1 smarcc1 (Catalog #AAA1267253) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCCGCAG CGGCGGGCGG CGGCGGGCCG GGGACAGCGG TAGGCGCCAC GGGCTCGGGG ATTGCGGCGG CAGCCGCAGG CCTAGCTGTT TATCGACGGA AGGATGGGGG CCCGGCCACC AAGTTTTGGG AGAGCCCGGA GACGGTGTCC CAGCTGGATT CGGTGCGGGT CTGGCTGGGC AAGCACTACA AGAAGTATGT TCATGCGGAT GCTCCTACCA ATAAAACACT GGCTGGGCTG GTGGTGCAGC TTCTTCAGTT CCAGGAAGAT GCCTTTGGGA AGCATGTCAC CAACCCGGCC TTCACCAAAC TCCCTGCAAA GTGTTTCATG GATTTCAAAG CTGGAGGCGC CTTATGTCAC ATTCTTGGGG CTGCTTACAA GTATAAAAAT GAACAGGGAT GGCGGAGGTT TGACCTACAG AACCCATCTC GAATGGATCG TAATGTGGAA ATGTTTATGA ACATTGAAAA AACATTGGTG CAGAACAATT GTTTGACCAG ACCCAACATC TACCTCATTC CAGACATTGA TCTGAAGTTG GCTAACAAAT TGAAAGATAT CATCAAACGA CATCAGGGAA CATTTACGGA TGAGAAGTCA AAAGCTTCCC ACCACATTTA CCCATATTCT TCCTCACAAG ACGATGAAGA ATGGTTGAGA CCGGTGATGA GAAAAGAGAA GCAAGTGTTA GTGCATTGGG GCTTTTACCC AGACAGCTAT GATACTTGGG TCCATAGTAA TGATGTTGAT GCTGAAATTG AAGATCCACC AATTCCAGAA AAACCATGGA AGGTTCATGT GAAATGGATT TTGGACACTG ATATTTTCAA TGAATGGATG AATGAGGAGG ATTATGAGGT GGATGAAAAT AGGAAGCCTG TGAGTTTTCG TCAGCGGATT TCAACCAAGA ATGAAGAGCC AGTCAGAAGT CCAGAAAGAA GAGATAGAAA AGCATCAGCT AATGCTCGAA AGAGGAAACA TTCGCCTTCG CCTCCCCCTC CGACACCAAC AGAATCACGG AAGAAGAGTG GGAAGAAAGG CCAAGCTAGC CTTTATGGGA AGCGCAGAAG TCAGAAAGAG GAAGATGAGC AAGAAGATCT AACCAAGGAT ATGGAAGACC CAACACCTGT ACCCAATATA GAAGAAGTAG TACTTCCCAA AAATGTGAAC CTAAAGAAAG ATAGTGAAAA TACACCTGTT AAAGGAGGAA CTGTAGCGGA TCTAGATGAG CAGGATGAAG AAACAGTCAC AGCAGGAGGA AAGGAAGATG AAGATCCTGC CAAAGGTGAT CAGAGTCGAT CAGTTGACCT TGGGGAAGAT AATGTGACAG AGCAGACCAA TCACATTATT ATTCCTAGTT ATGCATCATG GTTTGATTAT AACTGTATTC ATGTGATTGA ACGGCGTGCT CTTCCTGAGT TCTTCAATGG AAAAAACAAA TCCAAGACTC CAGAAATATA CTTGGCATAT CGAAATTTTA TGATTGACAC GTATCGTCTA AACCCCCAAG AGTATTTAAC TAGCACTGCT TGTCGGAGGA ACTTGACTGG AGATGTGTGT GCTGTGATGA GGGTCCATGC CTTTTTAGAG CAGTGGGGAC TCGTTAATTA CCAAGTTGAC CCGGAAAGTA GACCCATGGC AATGGGACCT CCTCCTACTC CTCATTTTAA TGTATTAGCT GATACCCCCT CTGGGCTTGT GCCTCTGCAT CTTCGATCAC CTCAGGTTCC TGCTGCTCAA CAGATGCTAA ATTTTCCTGA GAAAAACAAG GAAAAACCAG TTGATTTGCA GAACTTTGGT CTCCGTACTG ACATTTACTC CAAGAAAACA TTAGCAAAGA GTAAAGGTGC TAGTGCTGGA AGAGAATGGA CTGAACAGGA GACCCTTCTA CTCCTGGAGG CCCTGGAGAT GTACAAGGAT GATTGGAACA AAGTGTCGGA ACATGTTGGA AGTCGTACTC AGGATGAATG CATCCTCCAC TTTTTGAGAC TTCCCATTGA GGACCCATAC CTTGAGAATT CAGATGCTTC CCTTGGGCCT TTGGCCTACC AGCCTGTCCC CTTCAGTCAG TCAGGAAATC CAGTTATGAG TACTGTTGCT TTTTTGGCAT CTGTGGTGGA CCCTCGCGTG GCATCTGCTG CAGCAAAAGC GGCTTTGGAG GAGTTTTCTC GGGTCCGGGA GGAGGTACCA CTGGAATTGG TTGAAGCTCA TGTCAAGAAA GTACAAGAAG CAGCACGAGC CTCTGGGAAA GTGGATCCCA CCTACGGTCT GGAGAGCAGC TGCATTGCAG GCACAGGGCC CGATGAGCCA GAGAAGCTTG AAGGAGCTGA AGAGGAAAAA ATGGAAGCCG ACCCTGATGG TCAGCAGCCT GAAAAGGCAG AAAATAAAGT GGAAAATGAA ACGGATGAAG GTGATAAAGC ACAAGATGGA GAAAATGAAA AAAATAGTGA AAAGGAACAG GATAGTGAAG TGAGTGAGGA TACCAAATCA GAAGAAAAGG AGACTGAAGA GAACAAAGAA CTCACTGATA CATGTAAAGA AAGAGAAAGT GATACTGGGA AGAAGAAAGT AGAACATGAA ATTTCCGAAG GAAATGTTGC CACAGCCGCA GCAGCTGCTC TTGCCTCAGC GGCTACCAAA GCCAAGCACC TGGCTGCAGT GGAAGAAAGA AAGATCAAGT CCCTGGTAGC TCTCTTGGTT GAGACACAAA TGAAGAAACT AGAGATCAAA CTTCGACATT TTGAAGAGCT GGAAACTATC ATGGACAGAG AGAAAGAAGC TCTAGAACAA CAGAGGCAGC AGTTGCTTAC TGAACGCCAA AACTTCCACA TGGAACAGCT GAAGTATGCT GAATTACGAG CACGACAGCA AATGGAACAG CAGCAGCATG GCCAGAACCC TCAACAGGCA CACCAGCACT CAGGAGGACC TGGCCTGGCC CCACTTGGAG CAGCAGGGCA CCCTGGCATG ATGCCTCATC AACAGCCCCC TCCCTACCCT CTGATGCACC ACCAGATGCC ACCACCTCAT CCACCCCAGC CAGGTCAGAT ACCAGGCCCA GGTTCCATGA TGCCCGGGCA GCACATGCCA GGCCGCATGA TTCCCACTGT TGCAGCCAAC ATCCACCCCT CTGGGAGTGG CCCTACCCCT CCTGGCATGC CACCAATGCC AGGAAACATC TTAGGACCCC GGGTACCCCT GACAGCACCT AACGGCATGT ATCCCCCTCC ACCACAGCAG CAGCCACCGC CACCACCACC TGCAGATGGG GTCCCTCCGC CTCCTGCTCC TGGCCCGCCA GCCTCAGCTG CTCCTTAG. It is sometimes possible for the material contained within the vial of "SMARCC1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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