RFC1 cdna clone
RFC1 cDNA Clone
Gene Names
RFC1; A1; RFC; PO-GA; RECC1; MHCBFB; RFC140
Synonyms
RFC1; RFC1 cDNA Clone; RFC1 cdna clone
Sequence
atggacattcggaaattctttggagtaataccaagtggaaagaaacttgtaagtgaaacagtaaagaagaatgagaaaacaaagtctgatgaagaaactttaaaagcaaagaaaggaataaaggaaatcaaggtaaatagctcccgtaaagaggatgacttcaaacaaaagcaaccaagcaagaaaaagaggatcatctatgattcagattcagagtcagaggagacgttgcaggtaaaaaatgccaaaaagccaccagaaaaactgccagtatcttctaaacctggtaaaatttcacggcaggatcctgttacatacatttcagaaacagatgaagaagatgactttatgtgtaagaaggcggcctctaaatcaaaagagaatggaagatctacaaatagtcatcttggaacatcaaacatgaaaaagaatgaagaaaacactaagaccaagaataagcctttatcaccaataaaacttacacccacatcagtacttgattattttggaactggaagtgtccaaagatctaataagaagatggtggcaagcaaaagaaaagagctttcacaaaatacagatgagtctggattaaatgatgaagccatcgccaagcaattacagcttgatgaagatgcggagctggagaggcagttgcatgaagatgaagagtttgccagaacattagccatgttggatgaagaacccaagaccaaaaaggctcgaaaggacacagaagcgggagaaacgttttcatctgtccaagccaatttaagtaaagcagaaaaacataaatatcctcataaagtaaaaacagcacaagtttcagatgaaagaaagagctacagtcctaggaagcaaagtaaatatgaaagttcaaaagaatctcagcaacattccaagtcatcagctgacaaaataggagaagtctcttctcccaaggccagttctaagctggcaattatgaaaagaaaagaagagagctcttataaagaaatagagcctgtggcctcaaaaagaaaagaaaatgccattaaattgaaaggagagacaaaaactcctaagaaaaccaaaagttctccagctaaaaaagagtctgtaagtcctgaagattctgaaaagaaacgcactaattatcaagcttatcgaagctacttaaatcgagaaggtcccaaggctctgggctccaaagaaataccaaagggagctgaaaattgcttggaaggccttatatttgtaatcacaggcgtgctggagtctattgaacgagatgaggccaagtctctaattgaacgttatgggggaaaagtaacaggaaatgtcagcaagaaaacaaattatcttgtcatgggtcgtgatagtggacagtccaagagtgataaggccgcagccttggggacaaaaattattgatgaagatggcctgttgaatctgattcggactatgccaggcaagaaatccaagtatgaaatagcagttgaaactgagatgaagaaagagtccaaactggagagaacaccccaaaaaaatgtccaaggaaaaagaaaaattagtccatctaaaaaggaatcagaatctaaaaagagcaggccgacttccaaaagggacagtttggcaaagacaataaaaaaggaaacagatgtgttttggaaaagcctggatttcaaggagcaggtggctgaggagacaagtggtgacagcaaggctaggaatttggctgatgacagcagtgaaaacaaagtggaaaatttgctctgggtggataaatataagccaacctcgctcaagaccataattggacagcaaggtgaccagagctgtgccaacaaactcctacgctggctccgaaactggcaaaagagttcttccgaagataaaaaacacgcagcaaagtttggtaaattttccggcaaagatgatggctctagttttaaagcagcgttgctgtcaggccctcctggtgttggcaaaaccaccacagcttccctggtgtgtcaggagttgggatacagctacgtggaactgaatgcaagtgacacccggagtaagagcagtttgaaggcgattgttgctgagtcactgaacaataccagcatcaaaggcttttattcaaatggagcagcctcttcagtaagcacgaaacatgctctcatcatggatgaagtagatggcatggcaggcaatgaggataggggaggaattcaggaattaattggcctgataaaacatactaaaattcccattatttgtatgtgcaatgatagaaatcatcccaagattcgctctctggttcattattgttttgatcttcgttttcaaagacctcgggttgaacagattaagggtgctatgatgtctattgcatttaaagaaggtttaaagattccccctccagctatgaatgaaataattttgggagccaatcaagatatcagacaggttttacataatctgagtatgtggtgtgcacgaagtaaagcattaacctatgaccaggccaaagctgattctcacagagccaaaaaggatatcaaaatgggcccgtttgatgttgcccggaaagtgtttgcagctggagaggagactgctcacatgtcacttgtggacaagtcagatctcttttttcatgattattcaatagcacccctcttcgtccaggaaaattacatacacgtgaagcctgtagcagcagggggtgacatgaaaaagcacctgatgcttttaagcagagcagcagacagcatatgcgatggtgacctagtggacagccagatccggagtaagcaaaactggagtcttctgcctgcgcaggccatttatgccagtgttcttcctggagagttgatgagggggtacatgacccagtttcccaccttcccaagctggctggggaagcactcgtctacaggcaaacatgatcgtattgttcaggacctggccttgcatatgagtctcagaacttactccagcaaaaggactgtaaacatggattatctgtcgcttctaagggatgcacttgtacagcccttgacctcacaaggagtagacggagtacaggatgttgttgcacttatggacacatattatttgatgaaagaagactttgagaatatcatggaaatcagcagctggggtggcaaacctagtcccttttcaaagctggatcccaaggtgaaagcagccttcacaagagcttacaataaggaagcccaccttactccatactcacttcaagctataaaggcatctagacacagcacaagcccatccctggattcggaatacaatgaagaattaaatgaagatgactctcaatctgatgagaaagaccaagatgctatagaaactgatgccatgatcaagaaaaagacaaaatcttcaaagccttcaaaaccagaaaaagataaggagcccagaaaaggaaaaggaaaaagttcgaagaaatga
Sequence Length
3447
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
128,183 Da
NCBI Official Full Name
Homo sapiens replication factor C (activator 1) 1, 145kDa, mRNA
NCBI Official Synonym Full Names
replication factor C subunit 1
NCBI Official Symbol
RFC1
NCBI Official Synonym Symbols
A1; RFC; PO-GA; RECC1; MHCBFB; RFC140
NCBI Protein Information
replication factor C subunit 1
UniProt Protein Name
Replication factor C subunit 1
Protein Family
UniProt Gene Name
RFC1
UniProt Synonym Gene Names
RFC140; A1 140 kDa subunit; RF-C 140 kDa subunit; RFC140
UniProt Entry Name
RFC1_HUMAN
NCBI Description
This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]
Uniprot Description
RFC1: a DNA binding protein that may play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and RFC1. The RFC1 subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Two alternatively spliced isoforms have been described.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 4p14-p13
Cellular Component: DNA replication factor C complex; nucleoplasm; nucleus
Molecular Function: DNA binding; enzyme activator activity; protein binding
Biological Process: bypass DNA synthesis; DNA damage response, detection of DNA damage; DNA-dependent DNA replication; error-prone postreplication DNA repair; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; telomere maintenance via recombination; telomere maintenance via telomerase; transcription-coupled nucleotide-excision repair
Research Articles on RFC1
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Product Notes
The RFC1 rfc1 (Catalog #AAA1275494) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggacattc ggaaattctt tggagtaata ccaagtggaa agaaacttgt aagtgaaaca gtaaagaaga atgagaaaac aaagtctgat gaagaaactt taaaagcaaa gaaaggaata aaggaaatca aggtaaatag ctcccgtaaa gaggatgact tcaaacaaaa gcaaccaagc aagaaaaaga ggatcatcta tgattcagat tcagagtcag aggagacgtt gcaggtaaaa aatgccaaaa agccaccaga aaaactgcca gtatcttcta aacctggtaa aatttcacgg caggatcctg ttacatacat ttcagaaaca gatgaagaag atgactttat gtgtaagaag gcggcctcta aatcaaaaga gaatggaaga tctacaaata gtcatcttgg aacatcaaac atgaaaaaga atgaagaaaa cactaagacc aagaataagc ctttatcacc aataaaactt acacccacat cagtacttga ttattttgga actggaagtg tccaaagatc taataagaag atggtggcaa gcaaaagaaa agagctttca caaaatacag atgagtctgg attaaatgat gaagccatcg ccaagcaatt acagcttgat gaagatgcgg agctggagag gcagttgcat gaagatgaag agtttgccag aacattagcc atgttggatg aagaacccaa gaccaaaaag gctcgaaagg acacagaagc gggagaaacg ttttcatctg tccaagccaa tttaagtaaa gcagaaaaac ataaatatcc tcataaagta aaaacagcac aagtttcaga tgaaagaaag agctacagtc ctaggaagca aagtaaatat gaaagttcaa aagaatctca gcaacattcc aagtcatcag ctgacaaaat aggagaagtc tcttctccca aggccagttc taagctggca attatgaaaa gaaaagaaga gagctcttat aaagaaatag agcctgtggc ctcaaaaaga aaagaaaatg ccattaaatt gaaaggagag acaaaaactc ctaagaaaac caaaagttct ccagctaaaa aagagtctgt aagtcctgaa gattctgaaa agaaacgcac taattatcaa gcttatcgaa gctacttaaa tcgagaaggt cccaaggctc tgggctccaa agaaatacca aagggagctg aaaattgctt ggaaggcctt atatttgtaa tcacaggcgt gctggagtct attgaacgag atgaggccaa gtctctaatt gaacgttatg ggggaaaagt aacaggaaat gtcagcaaga aaacaaatta tcttgtcatg ggtcgtgata gtggacagtc caagagtgat aaggccgcag ccttggggac aaaaattatt gatgaagatg gcctgttgaa tctgattcgg actatgccag gcaagaaatc caagtatgaa atagcagttg aaactgagat gaagaaagag tccaaactgg agagaacacc ccaaaaaaat gtccaaggaa aaagaaaaat tagtccatct aaaaaggaat cagaatctaa aaagagcagg ccgacttcca aaagggacag tttggcaaag acaataaaaa aggaaacaga tgtgttttgg aaaagcctgg atttcaagga gcaggtggct gaggagacaa gtggtgacag caaggctagg aatttggctg atgacagcag tgaaaacaaa gtggaaaatt tgctctgggt ggataaatat aagccaacct cgctcaagac cataattgga cagcaaggtg accagagctg tgccaacaaa ctcctacgct ggctccgaaa ctggcaaaag agttcttccg aagataaaaa acacgcagca aagtttggta aattttccgg caaagatgat ggctctagtt ttaaagcagc gttgctgtca ggccctcctg gtgttggcaa aaccaccaca gcttccctgg tgtgtcagga gttgggatac agctacgtgg aactgaatgc aagtgacacc cggagtaaga gcagtttgaa ggcgattgtt gctgagtcac tgaacaatac cagcatcaaa ggcttttatt caaatggagc agcctcttca gtaagcacga aacatgctct catcatggat gaagtagatg gcatggcagg caatgaggat aggggaggaa ttcaggaatt aattggcctg ataaaacata ctaaaattcc cattatttgt atgtgcaatg atagaaatca tcccaagatt cgctctctgg ttcattattg ttttgatctt cgttttcaaa gacctcgggt tgaacagatt aagggtgcta tgatgtctat tgcatttaaa gaaggtttaa agattccccc tccagctatg aatgaaataa ttttgggagc caatcaagat atcagacagg ttttacataa tctgagtatg tggtgtgcac gaagtaaagc attaacctat gaccaggcca aagctgattc tcacagagcc aaaaaggata tcaaaatggg cccgtttgat gttgcccgga aagtgtttgc agctggagag gagactgctc acatgtcact tgtggacaag tcagatctct tttttcatga ttattcaata gcacccctct tcgtccagga aaattacata cacgtgaagc ctgtagcagc agggggtgac atgaaaaagc acctgatgct tttaagcaga gcagcagaca gcatatgcga tggtgaccta gtggacagcc agatccggag taagcaaaac tggagtcttc tgcctgcgca ggccatttat gccagtgttc ttcctggaga gttgatgagg gggtacatga cccagtttcc caccttccca agctggctgg ggaagcactc gtctacaggc aaacatgatc gtattgttca ggacctggcc ttgcatatga gtctcagaac ttactccagc aaaaggactg taaacatgga ttatctgtcg cttctaaggg atgcacttgt acagcccttg acctcacaag gagtagacgg agtacaggat gttgttgcac ttatggacac atattatttg atgaaagaag actttgagaa tatcatggaa atcagcagct ggggtggcaa acctagtccc ttttcaaagc tggatcccaa ggtgaaagca gccttcacaa gagcttacaa taaggaagcc caccttactc catactcact tcaagctata aaggcatcta gacacagcac aagcccatcc ctggattcgg aatacaatga agaattaaat gaagatgact ctcaatctga tgagaaagac caagatgcta tagaaactga tgccatgatc aagaaaaaga caaaatcttc aaagccttca aaaccagaaa aagataagga gcccagaaaa ggaaaaggaa aaagttcgaa gaaatga. It is sometimes possible for the material contained within the vial of "RFC1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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