RBBP4 cdna clone
RBBP4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Uniprot Description
RBBP4: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Interacts with SUV39H1 and HDAC7. Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the chromatin assembly factor 1 (CAF-1) complex, which is composed of RBBP4, CHAF1B and CHAF1A. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associate with HDAC1. Component of the PRC2/EED- EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1). Interacts with SPEN/MINT. Interacts with BRCA1. Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1p35.1
Cellular Component: ESC/E(Z) complex; nuclear chromatin; nucleoplasm; nucleus; NuRD complex; protein complex
Molecular Function: DNA-dependent ATPase activity; histone deacetylase activity; histone deacetylase binding; nucleosomal DNA binding; protein binding
Biological Process: ATP-dependent chromatin remodeling; chromatin assembly; chromatin remodeling; DNA replication-dependent nucleosome assembly; DNA replication-independent nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; negative regulation of cell proliferation; negative regulation of gene expression, epigenetic; regulation of cell cycle
Research Articles on RBBP4
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Product Notes
The RBBP4 rbbp4 (Catalog #AAA1276988) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggccgaca aggaagcagc cttcgacgac gcagtggaag aacgagtgat caacgaggaa tacaaaatat ggaaaaagaa cacccctttt ctttatgatt tggtgatgac ccatgctctg gagtggccca gcctaactgc ccagtggctt ccagatgtaa ccagaccaga agggaaagat ttcagcattc atcgacttgt cctggggaca cacacatcgg atgaacaaaa ccatcttgtt atagccagtg tgcagctccc taatgatgat gctcagtttg atgcgtcaca ctacgacagt gagaaaggag aatttggagg ttttggttca gttagtggaa aaattgaaat agaaatcaag atcaaccatg aaggagaagt aaacagggcc cgttatatgc cccagaaccc ttgtatcatc gcaacaaaga ctccttccag tgatgttctt gtctttgact atacaaaaca tccttctaaa ccagatcctt ctggagagtg caacccagac ttgcgtctcc gtggacatca gaaggaaggc tatgggcttt cttggaaccc aaatctcagt gggcacttac ttagtgcttc agatgaccat accatctgcc tgtgggacat cagtgccgtt ccaaaggagg gaaaagtggt agatgcgaag accatcttta cagggcatac ggcagtagta gaagatgttt cctggcatct actccatgag tctctgtttg ggtcagttgc tgatgatcag aaacttatga tttgggatac tcgttcaaac aatacttcca aacccagcca ctcagttgat gctcacactg ctgaagtgaa ctgcctttct ttcaatcctt atagtgagtt cattcttgcc acaggatcag ctgacaagac tgttgccttg tgggatctga gaaatctgaa acttaagttg cattcctttg agtcacataa ggatgaaata ttccaggttc agtggtcacc tcacaatgag actattttag cttccagtgg tactgatcgc agactgaatg tctgggattt aagtaaaatt ggagaggaac aatccccaga agatgcagaa gacgggccac cagagttgtt gtttattcat ggtggtcata ctgccaagat atctgatttc tcctggaatc ccaatgaacc ttgggtgatt tgttctgtat cagaagacaa tatcatgcaa gtgtggcaaa tggcagagaa catttataat gatgaagacc ctgaaggaag cgtggatcca gaaggacaag ggtcctag. It is sometimes possible for the material contained within the vial of "RBBP4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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