RASGRP2 cdna clone
RASGRP2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Description
RASGRP2 iso2: Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. Belongs to the RASGRP family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs; GEFs, Ras
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: cytosol; plasma membrane
Molecular Function: calcium ion binding; guanyl-nucleotide exchange factor activity; lipid binding
Biological Process: positive regulation of GTPase activity; signal transduction
Disease: Bleeding Disorder, Platelet-type, 18
Research Articles on RASGRP2
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Product Notes
The RASGRP2 rasgrp2 (Catalog #AAA1276108) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcaggca ccctggacct ggacaagggc tgcacggtgg aggagctgct ccgcgggtgc atcgaagcct tcgatgactc cgggaaggtg cgggacccgc agctggtgcg catgttcctc atgatgcacc cctggtacat cccctcctct cagctggcgg ccaagctgct ccacatctac caacaatccc ggaaggacaa ctccaattcc ctgcaggtga aaacgtgcca cctggtcagg tactggatct ccgccttccc agcggagttt gacttgaacc cggagttggc tgagcagatc aaggagctga aggctctgct agaccaagaa gggaaccgac ggcacagcag cctaatcgac atagacagcg tccctaccta caagtggaag cggcaggtga ctcagcggaa ccctgtggga cagaaaaagc gcaagatgtc cctgttgttt gaccacctgg agcccatgga gctggcggag catctcacct acttggagta tcgctccttc tgcaagatcc tgtttcagga ctatcacagt ttcgtgactc atggctgcac tgtggacaac cccgtcctgg agcggttcat ctccctcttc aacagcgtct cacagtgggt gcagctcatg atcctcagca aacccacagc cccgcagcgg gccctggtca tcacacactt tgtccacgtg gcggagaagc tgctacagct gcagaacttc aacacgctga tggcagtggt cgggggcctg agccacagct ccatctcccg cctcaaggag acccacagcc acgttagccc tgagaccatc aagctctggg agggtctcac ggaactagtg acggcgacag gcaactatgg caactaccgg cgtcggctgg cagcctgtgt gggcttccgc ttcccgatcc tgggtgtgca cctcaaggac ctggtggccc tgcagctggc actgcctgac tggctggacc cagcccggac ccggctcaac ggggccaaga tgaagcagct ctttagcatc ctggaggagc tggccatggt gaccagcctg cggccaccag tacaggccaa ccccgacctg ctgagcctgc tcacggtgtc tctggatcag tatcagacgg aggatgagct gtaccagctg tccctgcagc gggagccgcg ctccaagtcc tcgccaacca gccccacgag ttgcacccca ccaccccggc ccccggtact ggaggagtgg acctcggctg ccaaacccaa gctggatcag gccctcgtgg tggagcacat cgagaagatg gtggagtctg tgttccggaa ctttgacgtc gatggggatg gccacatctc acaggaagaa ttccagatca tccgtgggaa cttcccttac ctcagcgcct ttggggacct cgaccagaac caggatggct gcatcagcag ggaggagatg gtttcctatt tcctgcgctc cagctctgtg ttgggggggc gcatgggctt cgtacacaac ttccaggaga gcaactcctt gcgccccgtc gcctgccgcc actgcaaagc cctgatcctg ggcatctaca agcagggcct caaatgccga gcctgtggag tgaactgcca caagcagtgc aaggatcgcc tgtcagttga gtgtcggcgc agggcccaga gtgtgagcct ggaggggtct gcaccctcac cctcacccat gcacagccac catcaccgcg ccttcagctt ctctctgccc cgccctggca ggcgaggctc caggcctcca gagatccgtg aggaggaggt acagacggtg gaggatgggg tgtttgacat ccacttgtaa. It is sometimes possible for the material contained within the vial of "RASGRP2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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