RAPGEF2 cdna clone
RAPGEF2 cDNA Clone
Gene Names
RAPGEF2; RA-GEF; NRAPGEP; PDZGEF1; Rap-GEP; CNrasGEF; PDZ-GEF1; RA-GEF-1; nRap GEP
Synonyms
RAPGEF2; RAPGEF2 cDNA Clone; RAPGEF2 cdna clone
Sequence
atgggccagcaggagaaacactcacttcctgcagatttcacaaaactgcatcttactgacagtctccacccacaggtgacccacgtttcttctagccattcaggatgtagtatcactagtgattctgggagcagcagtctttctgatatctaccaggccacagaaagcgaggctggtgatatggacctgagtgggttgccagaaacagcagtggattccgaagacgacgacgatgaagaagacattgagagagcatcagatcctctgatgagcagggacattgtgagagactgcctagagaaggacccaattgaccggacagatgatgacattgaacaactcttggaatttatgcaccagttgcctgcttttgccaatatgacaatgtcagtgaggcgagaactctgtgctgtgatggtgttcgcagtggtggaaagagcagggaccatagtgttaaatgatggtgaagagctggactcctggtcagtgattctcaatggatctgtggaagtgacttatccagatggaaaagcagaaatactgtgcatgggaaatagttttggtgtctctcctaccatggacaaagaatacatgaaaggagtgatgagaacaaaggtggatgactgccagtttgtctgcatagcccagcaagattactgccgtattctcaatcaagtagaaaagaacatgcaaaaagttgaagaggaaggagagattgttatggtgaaagaacaccgagaacttgatcgaactggaacaagaaagggacacattgtcatcaagggtacctcagaaaggttaacaatgcatttggtggaagagcattcagtagtagatccaacattcatagaagactttctgttgacctataggacttttctttctagcccaatggaagtgggcaaaaagttattggagtggtttaatgacccgagcctcagggataaggttacacgggtagtattattgtgggtaaataatcacttcaatgactttgaaggagatcctgcaatgactcgatttttagaagaatttgaaaacaatctggaaagagagaaaatgggtggacacctaaggctgttgaatatcgcgtgtgctgctaaagcaaaaagaagattgatgacgttaacaaaaccatcccgagaagctcctttgccttttatcttacttggaggctctgagaagggatttggaatctttgttgacagtgtagattcaggtagcaaagcaactgaagcaggcttgaaacggggggatcagatattagaagtaaatggccaaaactttgaaaacattcagctgtcaaaagctatggaaattcttagaaataacacacatttatctatcactgtgaaaaccaatttatttgtatttaaagaacttctaacaagattgtcagaagagaaaagaaatggtgccccccaccttcctaaaattggtgacattaaaaaggccagtcgctactccattccagatcttgctgtagatgtagaacaggtgataggacttgaaaaagtgaacaaaaaaagtaaagccaacactgtgggaggaaggaacaagctgaaaaagatactcgacaagactcggatcagtatcttgccacagaaaccatacaatgatattgggattggtcagtctcaagatgacagcatagtaggattaaggcagacaaagcacatcccaactgcattgcctgtcagtggaaccttatcatccagtaatcctgatttattgcagtcacatcatcgcattttagacttcagtgctactcctgacttgccagatcaagtgctaagggtttttaaggctgatcagcaaagccgctacatcatgatcagtaaggacactacagcaaaggaagtggtcattcaggctatcagggagtttgctgttactgccaccccggatcaatattcactatgtgaggtctctgtcacacctgagggagtaatcaaacaaagaagacttccagatcagctttccaaacttgcagacagaatacaactgagtggaaggtattatctgaaaaacaacatggaaacagaaactctttgttcagatgaagatgctcaggagttgttgagagagagtcaaatttccctccttcagctcagcactgtggaagttgcaacacagctctctatgcgaaattttgaactctttcgcaacattgaacctactgaatatatagatgatttatttaaactcagatcaaaaaccagctgtgccaacctgaagagatttgaagaagtcattaaccaggaaacattttgggtagcatctgaaattctcagagaaacaaaccagctgaagaggatgaagatcattaagcatttcatcaagatagcactgcactgtagggaatgcaagaattttaactcaatgtttgcaatcatcagtggcctaaacctggcaccagtggcaagactgcgaacgacctgggagaaacttcccaataaatacgaaaaactatttcaagatctccaagacctgtttgatccttccagaaacatggcaaaatatcgtaatgttctcaatagtcaaaatctacaacctcccataatccctctattcccagttatcaaaaaggatctcaccttccttcacgaaggaaatgactcaaaagtagacgggctggtcaattttgagaagctaaggatgattgcaaaagaaattcgtcacgttggccgaatggcttcagtgaacatggaccctgccctcatgttcaggactcggaagaagaaatggcggagtttggggtctctcagccagggtagtacaaatgcaacagtgctagatgttgctcagacaggtggtcataaaaagcgggtacgtcgtagttcctttctcaatgccaaaaagctttatgaagatgcccaaatggctcgaaaagtgaagcagtacctttccaatttggagctagaaatggacgaggagagtcttcagacattatctctgcagtgtgagccagcaaccaacacattgcctaagaatcctggtgacaaaaagcctgtcaaatccgagacctctccagtagctccaagggcagggtcacaacagaaagctcagtccctgccacagccccagcagcagccaccaccagcacataaaatcaaccagggactacaggttcccgccgtgtccctttatccttcacggaagaaagtgcccgtaaaggatctcccaccttttggcataaactctccacaagctttaaaaaaaattctttctttgtctgaagaaggaagtttggaacgtcacaagaaacaggctgaagatacaatatcaaatgcatcttcgcagctttcttctcctcctacttctccacagagttctccaaggaaaggctatactttggctcccagtggtactgtggataatttttcagattctggtcacagtgaaatttcttcacgatccagtattgttagcaattcgtcttttgactcagtgccagtctcactgcacgatgagaggcgccagaggcattctgtcagcatcgtggaaacaaacctagggatgggcaggatggagaggcggaccatgattgaacctgatcagtatagcttggggtcctatgcaccaatgtccgagggccgaggcttatatgctacagctacagtaatttcttctccaagcacagaggaactttcccaggatcagggggatcgcgcgtcacttgatgctgctgacagtggccgtgggagctggacgtcatgctcaagtggctcccatgataatatacagacgatccagcaccagagaagctgggagactcttccattcgggcatactcactttgattattcaggggatcctgcaggtttatgggcatcaagcagccatatggaccaaattatgttttctgatcatagcacaaagtataacaggcaaaatcaaagtagagagagccttgaacaagcccagtcccgagcaagctgggcgtcttccacaggttactggggagaagactcagaaggtgacacaggcacaataaagcggaggggtggaaaggatgtttctattgaagccgaaagcagtagcctaacgtctgtgactacggaagaaaccaagcctgtccccatgcctgcccacatagctgtggcatcaagtactacaaaggggctcattgcacgaaaggagggcaggtatcgagagcccccgcccacccctcccggctacattggaattcccattactgactttccagaagggcactcccatccagccaggaaaccgccggactacaacgtggcccttcagagatcgcggatggtcgcacgatcctccgacacagctgggccttcatccgtacagcagccacatgggcatcccaccagcagcaggcctgtgaacaaacctcagtggcataaaccgaacgagtctgacccgcgcctcgccccctatcagtcccaagggttttccaccgaggaggatgatgaacaagtttctgctgtttga
Sequence Length
4461
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
167,417 Da
NCBI Official Full Name
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 2, mRNA
NCBI Official Synonym Full Names
Rap guanine nucleotide exchange factor 2
NCBI Official Symbol
RAPGEF2
NCBI Official Synonym Symbols
RA-GEF; NRAPGEP; PDZGEF1; Rap-GEP; CNrasGEF; PDZ-GEF1; RA-GEF-1; nRap GEP
NCBI Protein Information
rap guanine nucleotide exchange factor 2
UniProt Protein Name
Rap guanine nucleotide exchange factor 2
Protein Family
UniProt Gene Name
RAPGEF2
UniProt Synonym Gene Names
KIAA0313; NRAPGEP; PDZGEF1; CNrasGEF; nRap GEP; PDZ-GEF1
UniProt Entry Name
RPGF2_HUMAN
NCBI Description
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Uniprot Description
RAPGEF2: Guanine nucleotide exchange factor (GEF) for Rap1A, Rap1B and Rap2B GTPases. Does not interact with cAMP or cGMP. Interacts with MAGI2. Highest expression levels in brain. Lower expression levels in heart, kidney, lung, and placenta.
Protein type: GEFs, Ras; GEFs; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4q32.1
Cellular Component: apical plasma membrane; cell soma; cytoplasm; cytosol; endocytic vesicle; intercellular junction; late endosome; membrane; neuron projection; perinuclear region of cytoplasm; plasma membrane; protein complex; synapse; tight junction
Molecular Function: beta-1 adrenergic receptor binding; cAMP binding; cGMP binding; GTPase activator activity; PDZ domain binding; protein binding; Rap guanyl-nucleotide exchange factor activity; Ras guanyl-nucleotide exchange factor activity; signal transducer activity; WW domain binding
Biological Process: blood vessel development; brain-derived neurotrophic factor receptor signaling pathway; cAMP-mediated signaling; forebrain neuron development; G-protein coupled receptor protein signaling pathway; MAPKKK cascade; microvillus biogenesis; negative regulation of cell proliferation; negative regulation of dendrite morphogenesis; negative regulation of melanin biosynthetic process; neurite development; neuron migration; neuropeptide signaling pathway; positive regulation of GTPase activity; positive regulation of protein binding; positive regulation of protein kinase activity; Rap protein signal transduction; regulation of synaptic plasticity; small GTPase mediated signal transduction; ventricular system development
Research Articles on RAPGEF2
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Product Notes
The RAPGEF2 rapgef2 (Catalog #AAA1277973) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgggccagc aggagaaaca ctcacttcct gcagatttca caaaactgca tcttactgac agtctccacc cacaggtgac ccacgtttct tctagccatt caggatgtag tatcactagt gattctggga gcagcagtct ttctgatatc taccaggcca cagaaagcga ggctggtgat atggacctga gtgggttgcc agaaacagca gtggattccg aagacgacga cgatgaagaa gacattgaga gagcatcaga tcctctgatg agcagggaca ttgtgagaga ctgcctagag aaggacccaa ttgaccggac agatgatgac attgaacaac tcttggaatt tatgcaccag ttgcctgctt ttgccaatat gacaatgtca gtgaggcgag aactctgtgc tgtgatggtg ttcgcagtgg tggaaagagc agggaccata gtgttaaatg atggtgaaga gctggactcc tggtcagtga ttctcaatgg atctgtggaa gtgacttatc cagatggaaa agcagaaata ctgtgcatgg gaaatagttt tggtgtctct cctaccatgg acaaagaata catgaaagga gtgatgagaa caaaggtgga tgactgccag tttgtctgca tagcccagca agattactgc cgtattctca atcaagtaga aaagaacatg caaaaagttg aagaggaagg agagattgtt atggtgaaag aacaccgaga acttgatcga actggaacaa gaaagggaca cattgtcatc aagggtacct cagaaaggtt aacaatgcat ttggtggaag agcattcagt agtagatcca acattcatag aagactttct gttgacctat aggacttttc tttctagccc aatggaagtg ggcaaaaagt tattggagtg gtttaatgac ccgagcctca gggataaggt tacacgggta gtattattgt gggtaaataa tcacttcaat gactttgaag gagatcctgc aatgactcga tttttagaag aatttgaaaa caatctggaa agagagaaaa tgggtggaca cctaaggctg ttgaatatcg cgtgtgctgc taaagcaaaa agaagattga tgacgttaac aaaaccatcc cgagaagctc ctttgccttt tatcttactt ggaggctctg agaagggatt tggaatcttt gttgacagtg tagattcagg tagcaaagca actgaagcag gcttgaaacg gggggatcag atattagaag taaatggcca aaactttgaa aacattcagc tgtcaaaagc tatggaaatt cttagaaata acacacattt atctatcact gtgaaaacca atttatttgt atttaaagaa cttctaacaa gattgtcaga agagaaaaga aatggtgccc cccaccttcc taaaattggt gacattaaaa aggccagtcg ctactccatt ccagatcttg ctgtagatgt agaacaggtg ataggacttg aaaaagtgaa caaaaaaagt aaagccaaca ctgtgggagg aaggaacaag ctgaaaaaga tactcgacaa gactcggatc agtatcttgc cacagaaacc atacaatgat attgggattg gtcagtctca agatgacagc atagtaggat taaggcagac aaagcacatc ccaactgcat tgcctgtcag tggaacctta tcatccagta atcctgattt attgcagtca catcatcgca ttttagactt cagtgctact cctgacttgc cagatcaagt gctaagggtt tttaaggctg atcagcaaag ccgctacatc atgatcagta aggacactac agcaaaggaa gtggtcattc aggctatcag ggagtttgct gttactgcca ccccggatca atattcacta tgtgaggtct ctgtcacacc tgagggagta atcaaacaaa gaagacttcc agatcagctt tccaaacttg cagacagaat acaactgagt ggaaggtatt atctgaaaaa caacatggaa acagaaactc tttgttcaga tgaagatgct caggagttgt tgagagagag tcaaatttcc ctccttcagc tcagcactgt ggaagttgca acacagctct ctatgcgaaa ttttgaactc tttcgcaaca ttgaacctac tgaatatata gatgatttat ttaaactcag atcaaaaacc agctgtgcca acctgaagag atttgaagaa gtcattaacc aggaaacatt ttgggtagca tctgaaattc tcagagaaac aaaccagctg aagaggatga agatcattaa gcatttcatc aagatagcac tgcactgtag ggaatgcaag aattttaact caatgtttgc aatcatcagt ggcctaaacc tggcaccagt ggcaagactg cgaacgacct gggagaaact tcccaataaa tacgaaaaac tatttcaaga tctccaagac ctgtttgatc cttccagaaa catggcaaaa tatcgtaatg ttctcaatag tcaaaatcta caacctccca taatccctct attcccagtt atcaaaaagg atctcacctt ccttcacgaa ggaaatgact caaaagtaga cgggctggtc aattttgaga agctaaggat gattgcaaaa gaaattcgtc acgttggccg aatggcttca gtgaacatgg accctgccct catgttcagg actcggaaga agaaatggcg gagtttgggg tctctcagcc agggtagtac aaatgcaaca gtgctagatg ttgctcagac aggtggtcat aaaaagcggg tacgtcgtag ttcctttctc aatgccaaaa agctttatga agatgcccaa atggctcgaa aagtgaagca gtacctttcc aatttggagc tagaaatgga cgaggagagt cttcagacat tatctctgca gtgtgagcca gcaaccaaca cattgcctaa gaatcctggt gacaaaaagc ctgtcaaatc cgagacctct ccagtagctc caagggcagg gtcacaacag aaagctcagt ccctgccaca gccccagcag cagccaccac cagcacataa aatcaaccag ggactacagg ttcccgccgt gtccctttat ccttcacgga agaaagtgcc cgtaaaggat ctcccacctt ttggcataaa ctctccacaa gctttaaaaa aaattctttc tttgtctgaa gaaggaagtt tggaacgtca caagaaacag gctgaagata caatatcaaa tgcatcttcg cagctttctt ctcctcctac ttctccacag agttctccaa ggaaaggcta tactttggct cccagtggta ctgtggataa tttttcagat tctggtcaca gtgaaatttc ttcacgatcc agtattgtta gcaattcgtc ttttgactca gtgccagtct cactgcacga tgagaggcgc cagaggcatt ctgtcagcat cgtggaaaca aacctaggga tgggcaggat ggagaggcgg accatgattg aacctgatca gtatagcttg gggtcctatg caccaatgtc cgagggccga ggcttatatg ctacagctac agtaatttct tctccaagca cagaggaact ttcccaggat cagggggatc gcgcgtcact tgatgctgct gacagtggcc gtgggagctg gacgtcatgc tcaagtggct cccatgataa tatacagacg atccagcacc agagaagctg ggagactctt ccattcgggc atactcactt tgattattca ggggatcctg caggtttatg ggcatcaagc agccatatgg accaaattat gttttctgat catagcacaa agtataacag gcaaaatcaa agtagagaga gccttgaaca agcccagtcc cgagcaagct gggcgtcttc cacaggttac tggggagaag actcagaagg tgacacaggc acaataaagc ggaggggtgg aaaggatgtt tctattgaag ccgaaagcag tagcctaacg tctgtgacta cggaagaaac caagcctgtc cccatgcctg cccacatagc tgtggcatca agtactacaa aggggctcat tgcacgaaag gagggcaggt atcgagagcc cccgcccacc cctcccggct acattggaat tcccattact gactttccag aagggcactc ccatccagcc aggaaaccgc cggactacaa cgtggccctt cagagatcgc ggatggtcgc acgatcctcc gacacagctg ggccttcatc cgtacagcag ccacatgggc atcccaccag cagcaggcct gtgaacaaac ctcagtggca taaaccgaac gagtctgacc cgcgcctcgc cccctatcag tcccaagggt tttccaccga ggaggatgat gaacaagttt ctgctgtttg a. It is sometimes possible for the material contained within the vial of "RAPGEF2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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