Structure
T-448 free base, Inhibitor
T-448 free base
Purity
>98% (HPLC)
Synonyms
T-448 free base; T448; T 448; inhibitor
Purity/Purification
>98% (HPLC)
Target
Histone Demethylase
Receptor
Histone Demethylase
Chemical Name
3-((1S, 2R)-2-(cyclobutylamino)cyclopropyl)-N-(5-methyl-1, 3, 4-thiadiazol-2-yl)benzamide
SMILES
CC1=NN=C(S1)NC(=O)C2=CC=CC(=C2)C3CC3NC4CCC4
Molecular Formula
C17H20N4OS
CAS Number
1597426-52-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for T-448 free base, inhibitor
T-448 free base (T448) is a specific inhibitor of LSD1 enzyme activity, enhances H3K4 methylation in primary cultured rat neurons but has little impact on LSD1-GFI1B complex in human TF-1a erythroblasts; increases brain H3K4 methylation and partially restored learning function in mice withnMDA receptor hypofunction, shows unique therapeutic approaches for central nervous system disorders associated with epigenetic dysregulation.
Product Categories/Family for T-448 free base, inhibitor
References
1. Matsuda S, et al. Neuropsychopharmacology. 2018 Dec 22. doi: 10.1038/s41386-018-0300-9.
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Product Notes
The T-448 free base (Catalog #AAA3602283) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "T-448 free base, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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