PNPLA1 cdna clone
PNPLA1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the patatin-like phospholipase (PNPLA) family, which is characterized by the presence of a highly conserved patatin domain. PNPLA family members have diverse lipolytic and acyltransferase activities, and are key elements in lipid metabolism. While other members of this family have been well characterized, the function of this gene remained an enigma. However, recent studies show that this gene is expressed in the skin epidermal keratinocytes, and has a role in glycerophospholipid metabolism in the cutaneous barrier. Consistent with these observations, mutations in this gene are associated with ichthyosis in human (autosomal recessive congenital ichthyoses, ARCI) and dog. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Uniprot Description
PNPLA1: Lipid hydrolase. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; EC 3.1.1.-
Chromosomal Location of Human Ortholog: 6p21.31
Cellular Component: cytoplasm; lipid particle; membrane
Molecular Function: triacylglycerol lipase activity
Biological Process: lipid homeostasis; triacylglycerol catabolic process
Disease: Ichthyosis, Congenital, Autosomal Recessive 10
Research Articles on PNPLA1
Similar Products
Product Notes
The PNPLA1 pnpla1 (Catalog #AAA1275797) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGTGCAGA TGATGAGGCA GTTTCTGTAC CGGGTCCTGC CCGAGGACTC CTACAAGGTC ACCACGGGGA AGCTCCATGT GAGCCTCACC CGCTTAACGG ACGGGGAGAA TGTGGTGGTT TCAGAGTTCA CGTCCAAGGA GGAGCTCATT GAGGCCCTAT ACTGCAGCTG CTTCGTCCCG GTGTACTGTG GCCTCATCCC CCCGACTTAC CGCGGTGTGA GGTACATCGA TGGGGGCTTC ACGGGCATGC AGCCCTGTGC CTTCTGGACC GACGCCATCA CCATCTCCAC CTTCAGTGGG CAGCAGGACA TCTGTCCCCG GGACTGCCCG GCCATCTTCC ACGACTTCCG CATGTTCAAC TGCTCCTTCC AGTTCTCCCT GGAGAACATC GCCAGGATGA CCCACGCATT GTTCCCCCCG GACCTGGTGA TCCTGCACGA TTACTACTAC CGAGGGTACG AGGATGCAGT TTTGTACTTG AGGCGGCTGA ATGCTGTTTA TCTTAATTCT TCCTCCAAGA GAGTGATTTT CCCCCGGGTG GAAGTGTACT GCCAGATAGA ACTCGCCCTT GGCAATGAGT GCCCTGAACG CAGTCAACCA AGCCTTCGAG CACGGCAGGC CAGTCTGGAA GGAGCCACAC AACCTCACAA GGAGTGGGTT CCCAAAGGGG ATGGAAGGGG CAGCCATGGT CCGCCTGTGT CCCAACCTGT GCAGACACTT GAATTCACAT GCGAGTCACC TGTTTCAGCA CCAGTCTCTC CACTTGAGCA GCCACCTGCA CAGCCACTGG CCTCTTCAAC TCCACTTTCT CTAAGTGGCA TGCCACCTGT ATCATTCCCA GCTGTGCACA AGCCACCCAG CTCCACACCT GGTTCATCAC TGCCCACCCC ACCACCTGGA CTGTCACCTC TGTCACCTCA GCAGCAGGTA CAACCGTCTG GATCACCAGC CAGATCCCTA CACTCTCAGG CACCCACTTC ACACAGGCCA TCCCTGGGGC CTTCAACTGT GGGGGCACCT CAAACACTGC CCCGAAGTTC TCTTTCAGCC TTCCCTGCTC AGCCACCTGT GGAGGAACTA GGCCAAGAAC AGCCCCAAGC TGTAGCTCTT CTTGTCTCTT CAAAACCAAA AAGCGCCGTG CCTCTGGTTC ATGTGAAGGA AACCGTCAGC AAGCCTTATG TAACGGAGAG CCCTGCTGAA GACTCAAACT GGGTGAATAA GGTCTTCAAG AAGAACAAGC AAAAGACAAG TGGCACCAGA AAAGGCTTCC CAAGACATTC GGGATCCAAA AAACCAAGCA GCAAAGTGCA GTGA. It is sometimes possible for the material contained within the vial of "PNPLA1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
