PHC1 cdna clone
PHC1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008]
Uniprot Description
PHC1: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: nucleoplasm; nucleus; PcG protein complex
Biological Process: histone ubiquitination; protein sumoylation
Disease: Microcephaly 11, Primary, Autosomal Recessive
Research Articles on PHC1
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Product Notes
The PHC1 phc1 (Catalog #AAA1275484) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgccaggta cagtgcagtc tggtcaggcc catttggcct cctcgccacc ttcatcccag gctcctggtg cactgcagga gtgccctccc acattggccc ctgggatgac ccttgctcct gtgcagggga cagcacatgt ggtaaagggt ggggctacca cctcctcacc tgttgtagcc caggtccctg ctgccttcta tatgcagtct gtgcacttgc cgggtaaacc ccagacattg gctgtcaaac gcaaggctga ctctgaggag gagagagatg atgtctccac attgggttca atgcttcctg ccaaggcatc tccagtagca gaaagcccaa aagtcatgga cgagaagagc agtcttggag aaaaagctga atcagtggct aatgtgaatg ctaatgctcc aagcagtgaa ctagtagcct tgacccccgc cccttcagta ccgcctccta cactagccat ggtgtctaga caaatgggtg actcaaaacc cccacaggcc atcgtgaagc cccagattct cacccacatc attgaaggct ttgttatcca ggaaggagca gaacctttcc cggtgggttg ttctcagtta ctgaaggagt ctgagaagcc actacagact ggccttccga cagggctgac tgagaatcag tcaggtggcc ctttgggagt ggacagccca tctgctgagt tagataagaa ggcgaatctc ctgaagtgcg agtactgtgg gaagtacgcc cccgcagagc agtttcgtgg ctctaagagg ttctgctcca tgacttgcgc taagaggtac aatgtgagct gtagccatca gttccggctg aagaggaaaa aaatgaaaga gtttcaagaa gccaactatg ctcgcgttcg caggcgtgga ccccgccgca gctcctctga cattgcccgt gccaagattc agggcaagtg ccaccggggt caagaagact ctagccgggg ttcagataat tccagttatg atgaagcact ctctccaaca tctcctgggc ctttatcagt aagagctggg catggagaac gtgacctggg gaatcccaat acagctccac ctacaccgga attacatggc atcaaccctg tgttcctgtc cagtaatccc agccgttgga gtgtagagga ggtgtacgag tttattgctt ctctccaagg ctgccaagag attgcagagg aatttcgctc acaggagatt gatggacagg cccttttatt acttaaagaa gaacatctta tgagtgccat gaacatcaag ctgggccctg ccctcaagat ctgcgccaag ataaatgtcc tcaaggagac ctaa. It is sometimes possible for the material contained within the vial of "PHC1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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