PASK cdna clone
PASK cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Description
PASK: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation. Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails. Protein kinase activity is inhibited by the first PAS domain: binding of an unidentified ligand desinhibits the protein kinase activity. May be activated by autophosphorylation on Thr-1161 and Thr-1165 (PubMed:11459942). The activating role of autophosphorylation at Thr-1161 is unclear: according to a report, autophosphorylation at Thr-1161 does not play a major role in activation (PubMed:20943661). Autophosphorylation is enhanced upon phosphatidylinositol monophosphate (phosphatidylinositol 4-phosphate) binding and inhibited upon phosphatidylinositol bi- and tri-phosphate binding. In contrast, phosphorylation of target proteins is inhibited upon all phosphatidylinositol-binding (phosphatidylinositol mono- bi- and tri-phosphate). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein kinase, CAMK; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMKL family; PASK subfamily
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: cytoplasm; Golgi apparatus; nucleus
Molecular Function: phosphoinositide binding; protein binding; protein serine/threonine kinase activity
Biological Process: negative regulation of glycogen biosynthetic process; positive regulation of translation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of respiratory gaseous exchange
Research Articles on PASK
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Product Notes
The PASK pask (Catalog #AAA1278711) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGAGGACG GGGGCTTAAC AGCCTTTGAA GAGGACCAGA GATGCCTTTC CCAGAGCCTC CCCTTGCCAG TGTCAGCAGA GGGCCCAGCT GCACAGACCA CTGCTGAGCC CAGCAGGTCG TTTTCCTCAG CCCACAGACA CCTGAGCAGA AGGAATGGGC TTTCCAGACT CTGCCAGAGC AGGACGGCGC TCTCTGAAGA CAGATGGAGC TCCTATTGTC TATCATCACT GGCTGCCCAG AATATTTGTA CAAGTAAACT GCACTGCCCT GCTGCCCCTG AGCACACGGA CCCGTCCGAA CCGCGGGGCA GTGTGTCCTG CTGCTCCCTG CTGCGGGGAC TGTCCTCAGG GTGGTCCTCA CCTCTGCTTC CGGCCCCTGT GTGCAACCCT AACAAGGCCA TCTTCACGGT GGATGCCAAG ACCACAGAGA TCCTGGTTGC TAACGACAAA GCTTGCGGGC TCCTGGGGTA CAGCAGCCAG GACCTGATTG GCCAGAAGCT CACGCAGTTC TTTCTGAGGT CAGATTCTGA TGTGGTGGAG GCCCTCAGCG AGGAGCACAT GGAGGCCGAC GGCCACGCTG CGGTGGTGTT TGGCACGGTG GTGGACATCA TCAGCCGTAG TGGGGAGAAG ATTCCAGTGT CTGTGTGGAT GAAGAGGATG CGGCAGGAGC GCCGCCTATG CTGCGTGGTG GTCCTGGAGC CCGTGGAGAG GGTCTCGACC TGGGTCGCTT TCCAGAGCGA TGGCACCATC ACGTCATGTG ACAGTCTCTT TGCTCATCTT CACGGGTACG TGTCTGGGGA GGACGTGGCT GGGCAGCATA TCACAGACCT GATCCCTTCT GTGCAGCTCC CTCCTTCTGG CCAGCACATC CCAAAGAATC TCAAGATTCA GAGGTCTGTT GGAAGAGCCA GGGACGGTAC CACCTTCCCT CTGAGCTTAA AGCTGAAATC CCAACCCAGC AGCGAGGAGG CGACCACCGG TGAGGCGGCC CCTGTGAGCG GCTACCGGGC ATCTGTCTGG GTGTTCTGCA CCATCAGTGG CCTCATCACC CTCCTGCCGG ATGGGACCAT CCACGGCATC AACCACAGCT TCGCGCTGAC ACTGTTTGGT TACGGAAAGA CGGAGCTCCT GGGCAAGAAT ATCACTTTCC TGATTCCTGG TTTCTACAGC TACATGGACC TTGCGTACAA CAGCTCATTA CAGCTCCCAG ACCTGGCCAG CTGCCTGGAC GTCGGCAATG AGAGTGGGTG TGGGGAGAGA ACCTTGGACC CGTGGCAGGG CCAGGACCCA GCTGAGGGGG GCCAGGATCC AAGGATTAAT GTCGTGCTTG CTGGTGGCCA CGTTGTGCCC CGAGATGAGA TCCGGAAGCT GATGGAAAGC CAAGACATCT TCACCGGGAC TCAGACTGAG CTGATTGCTG GAGGCCAGCT CCTTTCCTGC CTCTCACCTC AGCCTGCTCC AGGGGTGGAC AATGTCCCAG AAGGAAGCCT GCCAGTGCAC GGTGAACAGG CGCTGCCCAA GGACCAGCAA ATCACTGCCT TGGGGAGAGA GGAACCTGTG GCAATAGAGA GCCCCGGACA GGATCTTCTG GGAGAAAGCA GGTCTGAACC AGTGGATGTG AAGCCATTTG CTTCCTGCGA AGATTCTGAA GCTCCAGTCC CAGCTGAGGA TGGGGGCAGT GATGCTGGCA TGTGTGGCCT GTGTCAGAAG GCCCAGCTAG AGCGGATGGG AGTCAGTGGT CCCAGCGGTT CAGACCTTTG GGCTGGGGCT GCCGTGGCCA AGCCCCAGGC CAAGGGTCAG CTGGCGGGGG GCAGCCTCCT GATGCACTGC CCTTGCTATG GGAGTGAATG GGGCTTGTGG TGGCGAAGCC AGGACTTGGC CCCCAGCCCC TCTGGGATGG CAGGCCTCTC GTTTGGGACA CCTACTCTAG ATGAGCCGTG GCTGGGAGTG GAAAACGACC GAGAAGAGCT GCAGACCTGC TTGATTAAGG AGCAGCTGTC CCAGTTGAGC CTTGCGGGAG CCCTGGATGT CCCCCACGCC GAACTCGTTC CGACAGAGTG CCAGGCTGTC ACCGCTCCTG TGTCGTCCTG CGATCTGGGA GGCAGAGACC TGTGCGGTGG CTGCACGGGC AGCTCCTCAG CCTGCTATGC CTTGGCCACG GACCTCCCTG GGGGCCTGGA AGCAGTGGAG GCCCAGGAGG TTGATGTGAA TTCGTTTTCC TGGAACCTCA AGGAACTCTT TTTCAGTGAC CAGACAGACC AAACGTCATC AAATTGTTCC TGTGCTACGT CTGAACTCAG AGAGACACCC TCTTCCTTGG CAGTGGGCTC CGATCCAGAT GTAGGCAGTC TCCAGGAACA GGGGTCGTGT GTCCTGGATG ACAGGGAGCT GTTACTACTG ACCGGCACCT GTGTTGACCT TGGCCAAGGC CGACGGTTCC GGGAGAGCTG TGTGGGACAT GATCCAACAG AACCGCTTGA GGTTTGTTTG GTGTCCTCTG AGCATTATGC AGCAAGCGAC AGAGAAAGCC CAGGACACGT TCCTTCCACG TTGGATGCTG GCCCTGAGGA CACGTGCCCA TCAGCAGAGG AGCCAAGGCT GAACGTCCAG GTCACCTCCA CGCCCGTGAT CGTGATGCGC GGGGCTGCTG GCCTGCAGCG GGAGATCCAG GAGGGTGCCT ACTCCGGGAG CTGCTACCAT CGAGATGGCT TACGGCTGAG TATACAGTTT GAGGTGAGGC GGGTGGAGCT CCAGGGCCCC ACACCTCTGT TCTGCTGCTG GCTGGTGAAA GACCTCCTCC ACAGCCAACG CGACTCAGCC GCCAGGACCC GCCTGTTCCT TGCCAGCCTG CCCGGCTCCA CCCACTCTAC CGCTGCTGAG CTCACCGGAC CCAGCCTGGT GGAAGTGCTC AGAGCCAGAC CCTGGTTTGA GGAGCCCCCC AAGGCTGTGG AACTGGAGGG GTTGGCGGCC TGTGAGGGCG AGTACTCCCA AAAGTACAGT ACCATGAGCC CGCTGGGCAG TGGGGCCTTC GGCTTCGTGT GGACTGCTGT GGACAAGGAA AAAAACAAGG AGGTGGTGGT GAAGTTTATT AAGAAGGAGA AGGTCTTGGA GGATTGTTGG ATTGAGGATC CCAAACTTGG GAAAGTTACT TTAGAGATCG CAATTCTATC CAGGGTGGAG CATTCCAATA TCATCAAGGT ATTGGATATA TTTGAAAACC AAGGGTTCTT CCAGCTTGTG ATGGAGAAGC ACGGCTCCGG CCTAGACCTC TTCGCTTTCA TCGACCGCCA CCCCAGGCTG GATGAGCCCC TGGCGAGCTA CATCTTCCGA CAAGTGAGAG CAGGCCAGAG CCGTGTTAGT GTGAACGCAG GCCTGGGTGC CTGGGTCCGG TGGCTGCAAA GATCAGTGAT CCATACTCGG TTCTCTCTCT GA. It is sometimes possible for the material contained within the vial of "PASK, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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