PAPOLG cdna clone
PAPOLG cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]
Uniprot Description
PAP-gamma: a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. Shares 60% identity with poly(A) polymerase II (PAPII) at the amino acid level. Exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. Responsible for the post-transcriptional adenylation of the 3'-terminal several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. Ten alternatively spliced isoforms have been described.
Protein type: Transferase; EC 2.7.7.19
Chromosomal Location of Human Ortholog: 2p16.1
Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus
Molecular Function: metal ion binding; polynucleotide adenylyltransferase activity
Biological Process: mRNA polyadenylation; RNA polyadenylation
Research Articles on PAPOLG
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Product Notes
The PAPOLG papolg (Catalog #AAA1274730) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGAAAGAGA TGTCTGCAAA CACCGTGCTG GACAGCCAGC GTCAACAAAA GCATTATGGA ATTACCTCCC CAATTAGTTT GGCATCTCCT AAAGAAATTG ATCATATTTA CACACAGAAA TTAATTGACG CCATGAAACC ATTTGGAGTG TTTGAAGATG AGGAAGAATT GAACCACAGG CTGGTGGTTC TTGGTAAATT GAACAATTTA GTAAAAGAAT GGATTTCTGA TGTCAGCGAG AGTAAGAACC TCCCACCTTC TGTTGTGGCT ACTGTTGGTG GTAAAATTTT CACATTTGGA TCCTATAGGC TTGGAGTACA CACCAAAGGA GCTGACATTG ATGCACTTTG TGTAGCTCCA AGACATGTGG AAAGATCTGA TTTTTTTCAG TCTTTTTTTG AAAAATTGAA ACATCAAGAT GGCATTAGAA ACTTAAGAGC TGTAGAAGAT GCCTTTGTAC CTGTTATAAA ATTTGAATTT GATGGTATTG AAATTGATCT AGTCTTTGCA AGACTGGCAA TACAAACCAT ATCAGATAAT TTAGATCTAA GAGACGACTC TCGCCTGAGA AGCCTTGATA TAAGGTGTAT TCGCAGCTTA AATGGTTGTA GAGTTACTGA TGAAATTTTG CATTTAGTGC CAAATAAAGA AACTTTTAGA CTCACCCTAA GAGCTGTCAA ATTATGGGCA AAACGACGTG GTATTTATTC CAACATGCTA GGATTCCTTG GTGGTGTCTC CTGGGCAATG CTAGTTGCAA GAACTTGCCA ATTGTATCCA AATGCAGCAG CATCTACTTT AGTTCATAAG TTCTTTTTAG TTTTTTCCAA GTGGGAATGG CCAAATCCTG TGCTGCTGAA GCAACCAGAA GAAAGCAATT TGAATTTGCC TGTCTGGGAT CCTCGGGTAA ATCCATCAGA TAGGTATCAT CTCATGCCCA TAATCACCCC TGCCTACCCA CAACAGAATT CTACGTATAA TGTGTCCACA TCAACTCGAA CAGTAATGGT AGAAGAATTT AAACAAGGTC TTGCAGTCAC AGATGAAATT CTTCAAGGAA AGTCAGATTG GTCCAAACTA CTTGAGCCAC CGAATTTCTT TCAAAAGTAT AGACATTATA TAGTATTGAC TGCCAGCGCA TCAACAGAAG AAAACCATCT AGAGTGGGTT GGATTAGTAG AATCTAAAAT CCGTGTACTT GTTGGAAACT TGGAACGGAA TGAATTTATT ACTCTTGCCC ATGTGAATCC CCAGTCATTC CCAGGGAATA AGGAACATCA TAAAGACAAC AATTACGTAT CAATGTGGTT CCTTGGGATA ATTTTTCGGA GAGTAGAAAA TGCAGAAAGT GTCAACATAG ACTTGACATA TGATATACAG TCATTTACTG ATACAGTGTA CAGACAGGCA AACAATATAA ATATGCTAAA GGAGGGAATG AAAATTGAAG CAACTCATGT AAAGAAAAAA CAACTTCACC ACTACCTTCC TGCAGAAATT CTTCAAAAGA AGAAAAAGCA AAGTCTCTCT GATGTCAATC GAAGCTCGGG CGGACTTCAA TCCAAAAGAT TGTCTCTGGA TAGCAGTTGT CTGGATAGCT CCAGAGACAC TGATAATGGA ACACCTTTTA ATTCTCCAGC GTCCAAGTCT GATAGCCCTT CTGTAGGAGA AACAGAAAGG AATAGTGCTG AGCCTGCTGC TGTAATTGTG GAGAAGCCAC TGAGTGTACC ACCAGCCCAA GGACTTTCCA TTCCAGTGAT TGGCGCAAAA GTTGACTCTA CAGTAAAAAC TGTATCACCC CCCACTGTGT GTACCATTCC TACCGTAGTA GGACGAAATG TCATTCCTAG AATCACAACA CCTCACAACC CTGCCCAGGG ACAACCGCAT CTGAATGGAA TGTCAAATAT AACTAAGACT GTTACACCTA AGAGATCCCA TTCCCCATCC ATAGATGGGA CTCCTAAGAG GTTGAAAGAC GTAGAAAAGT TTATTCGACT TGAATCAACA TTTAAGGACC CCCGCACTGC TGAAGAAAGA AAAAGAAAAT CAGTGGATGC CATTGGAGGA GAATCTATGC CTATTCCAAC TATTGATACA TCACGCAAAA AGAGACTACC CAGTAAAGAA CTACCAGATT CATCATCTCC AGTTCCAGCA AACAACATCC GTGTCATCAA AAATTCCATT CGACTGACCC TTAATCGGTA A. It is sometimes possible for the material contained within the vial of "PAPOLG, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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